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Literature DB >> 8437713

Nonketotic hyperglycinemia: clinical and electrophysiologic effects of dextromethorphan, an antagonist of the NMDA receptor.

B Schmitt¹, B Steinmann, R Gitzelmann, L Thun-Hohenstein, H Mascher, G Dumermuth.

Abstract

A 10-week-old girl with nonketotic hyperglycinemia was treated with increasing amounts of dextromethorphan, an NMDA receptor antagonist. She improved neurologically; at 35 mg/kg/d, seizures ceased and EEG normalized. Dextromethorphan withdrawal resulted in a dramatic clinical deterioration coinciding with epileptic and high-voltage slow activity in the EEG. After reintroduction of dextromethorphan (35 mg/kg/d), recovery occurred within 24 hours.

Entities: Chemical Disease Species

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Year: 1993 PMID： 8437713 DOI： 10.1212/wnl.43.2.421

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

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Cited

11 in total

1. Treatment of late-onset nonketotic hyperglycinaemia: effectiveness of imipramine and benzoate.

Authors: E J Wiltshire; N K Poplawski; J R Harrison; J M Fletcher
Journal: J Inherit Metab Dis Date: 2000-02 Impact factor: 4.982

2. Prediction of long-term outcome in glycine encephalopathy: a clinical survey.

Authors: Julia B Hennermann; Jeanne-Marie Berger; Ulrike Grieben; Gunter Scharer; Johan L K Van Hove
Journal: J Inherit Metab Dis Date: 2011-10-15 Impact factor: 4.982

3. Dextromethorphan in molybdenum cofactor deficiency.

Authors: G Kurlemann; O Debus; G Schuierer
Journal: Eur J Pediatr Date: 1996-05 Impact factor: 3.183

4. Effect of sodium benzoate in the treatment of atypical nonketotic hyperglycinaemia.

Authors: J M Neuberger; S Schweitzer; M O Rolland; R Burghard
Journal: J Inherit Metab Dis Date: 2000-02 Impact factor: 4.982

5. Dextromethorphan in nonketotic hyperglycinaemia: metabolic variation confounds the dose-response relationship.

Authors: G L Arnold; M L Griebel; J L Valentine; D M Koroma; G L Kearns
Journal: J Inherit Metab Dis Date: 1997-03 Impact factor: 4.982

6. Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia.

Authors: Alana Pimentel Moura; Belisa Parmeggiani; Juciano Gasparotto; Mateus Grings; Gabriela Miranda Fernandez Cardoso; Bianca Seminotti; José Cláudio Fonseca Moreira; Daniel Pens Gelain; Moacir Wajner; Guilhian Leipnitz
Journal: Mol Neurobiol Date: 2017-01-03 Impact factor: 5.590

Nonketotic hyperglycinemia: clinical and electrophysiologic effects of dextromethorphan, an antagonist of the NMDA receptor.

1. Treatment of late-onset nonketotic hyperglycinaemia: effectiveness of imipramine and benzoate.

2. Prediction of long-term outcome in glycine encephalopathy: a clinical survey.

3. Dextromethorphan in molybdenum cofactor deficiency.

4. Effect of sodium benzoate in the treatment of atypical nonketotic hyperglycinaemia.

5. Dextromethorphan in nonketotic hyperglycinaemia: metabolic variation confounds the dose-response relationship.

6. Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia.

7. Drug refractory epilepsy in brain damage: effect of dextromethorphan on EEG in four patients.

8. Aluminum alters NMDA receptor 1A and 2A/B expression on neonatal hippocampal neurons in rats.

9. A rare case of glycine encephalopathy unveiled by valproate therapy.

Review 10. Why Not Glycine Electrochemical Biosensors?