| Literature DB >> 8437613 |
S L de Oliveira1, M F da Silva, A M Soares, C L Silva.
Abstract
The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the Fl fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.Entities:
Mesh:
Year: 1993 PMID: 8437613 DOI: 10.1007/bf01103346
Source DB: PubMed Journal: Mycopathologia ISSN: 0301-486X Impact factor: 2.574