Literature DB >> 8437076

Decision analysis in children with blunt splenic trauma: the effects of observation, splenorrhaphy, or splenectomy on quality-adjusted life expectancy.

V Velanovich1, D Tapper.   

Abstract

The management of blunt splenic trauma in children has remained controversial, with different physicians advocating observation, splenorrhaphy, and splenectomy. Proponents for each position have debated the relative importance of rebleeding (delayed splenic rupture), posttransfusion hepatitis with its sequelae, and overwhelming postsplenectomy sepsis. In an attempt to guide the clinician, a decision analysis was performed. Variables evaluated included the incidence of transfusion, postsplenectomy sepsis, posttransfusion hepatitis, chronic active hepatitis, cirrhosis, and rebleeding. The quality-adjusted life expectancies (QALEs) when the average incidence of the variables were used in the decision analysis were 62.69 years for observation, 62.32 years for splenorrhaphy, and 61.14 years for splenectomy. Sensitivity analysis showed that there was very little difference between observation and splenorrhaphy when the transfusion rate and hepatitis rate were varied. But these treatment options produced longer QALEs than splenectomy. Therefore, in appropriately selected patients, observation is a safe and effective therapeutic option. If an operation is necessary, every effort should be made to preserve the spleen. Splenectomy may still be required in those cases of complete devascularization, persistent hemorrhage, or other associated significant injuries.

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Year:  1993        PMID: 8437076     DOI: 10.1016/s0022-3468(05)80270-2

Source DB:  PubMed          Journal:  J Pediatr Surg        ISSN: 0022-3468            Impact factor:   2.545


  5 in total

Review 1.  Regeneration of autotransplanted splenic fragments: basic immunological and clinical relevance.

Authors:  R Pabst
Journal:  Clin Exp Immunol       Date:  1999-09       Impact factor: 4.330

2.  Case 2: An unusual cause of syncope.

Authors:  Caroline Calpin
Journal:  Paediatr Child Health       Date:  2005-02       Impact factor: 2.253

3.  Splenectomy after paediatric trauma: could more spleens be saved?

Authors:  P Godbole; M D Stringer
Journal:  Ann R Coll Surg Engl       Date:  2002-03       Impact factor: 1.891

4.  Quality of life in early adolescence: a sixteen-dimensional health-related measure (16D).

Authors:  M Apajasalo; H Sintonen; C Holmberg; J Sinkkonen; V Aalberg; H Pihko; M A Siimes; I Kaitila; A Mäkelä; K Rantakari; R Anttila; J Rautonen
Journal:  Qual Life Res       Date:  1996-04       Impact factor: 4.147

5.  Successful Nonoperative Management of Spontaneous Splenic Hematoma and Hemoperitoneum due to CMV Infection.

Authors:  Georgios Lianos; Eleftheria Ignatiadou; Christina Bali; Haralampos Harissis; Christos Katsios
Journal:  Case Rep Gastrointest Med       Date:  2012-11-28
  5 in total

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