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Literature DB >> 8436968

Stable expression and regulation of a rat brain K+ channel.

S D Critz¹, B A Wible, H S Lopez, A M Brown.

Abstract

The Shaw-type K+ channel Kv3.1 was stably transfected in human embryonic kidney cells. Voltage dependence of activation, K+ permeability, sensitivity to external tetraethylammonium, and unitary conductance were similar to Kv3.1 channels expressed transiently in Xenopus oocytes. Kv3.1 channels appear to be regulated because the protein kinase C activator phorbol 12,13-dibutyrate decreased Kv3.1 currents. Based on these results, we find that the stable expression of voltage-gated K+ channels in human embryonic kidney cells appears to be well suited for analysis of both biophysical and biochemical regulatory processes.

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Year: 1993 PMID： 8436968 DOI： 10.1111/j.1471-4159.1993.tb03273.x

Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372

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Cited

21 in total

1. The contribution of dendritic Kv3 K+ channels to burst threshold in a sensory neuron.

Authors: A J Rashid; E Morales; R W Turner; R J Dunn
Journal: J Neurosci Date: 2001-01-01 Impact factor: 6.167

2. Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current.

Authors: Kevin S Thorneloe; Mark T Nelson
Journal: J Physiol Date: 2003-04-04 Impact factor: 5.182

3. Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory neurons and transfected cells.

Authors: C M Macica; L K Kaczmarek
Journal: J Neurosci Date: 2001-02-15 Impact factor: 6.167

Review 4. Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish.

Authors: W H Mehaffey; F R Fernandez; A J Rashid; R J Dunn; R W Turner
Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Date: 2006-01-20 Impact factor: 1.836

10. Age-related decline in Kv3.1b expression in the mouse auditory brainstem correlates with functional deficits in the medial olivocochlear efferent system.

Authors: Martha L Zettel; Xiaoxia Zhu; William E O'Neill; Robert D Frisina
Journal: J Assoc Res Otolaryngol Date: 2007-02-15

Stable expression and regulation of a rat brain K+ channel.

1. The contribution of dendritic Kv3 K+ channels to burst threshold in a sensory neuron.

2. Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current.

3. Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory neurons and transfected cells.

Review 4. Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish.

5. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.

6. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion.

7. Redox modulation of hslo Ca2+-activated K+ channels.

8. Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.

9. The selectivity of different external binding sites for quaternary ammonium ions in cloned potassium channels.

10. Age-related decline in Kv3.1b expression in the mouse auditory brainstem correlates with functional deficits in the medial olivocochlear efferent system.