Literature DB >> 843584

Evidence that nystatin may not form channels in thin lipid membranes.

W O Romine, G R Sherette, G B Brown, R J Bradley.   

Abstract

The mechanism of nystatin-induced conductance increases in planar bilayer membranes formed from lecithin/cholesterol (1:1) has been examined by spectral analysis of kinetic fluctuations. Lorentzian components of the power spectrum, characteristic of channel activity, were not observed for nystatin-doped membranes. Instead, the noise associated with this system (approximately 10(-27)A2/Hz) was in better agreement with that expected of a carrier mechanism involved in the transport of single charges in uncorrelated fashion. The implications of this result with respect to previous models of nystatin-induced conductance increases are discussed.

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Year:  1977        PMID： 843584      PMCID： PMC1473235          DOI： 10.1016/S0006-3495(77)85655-5

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  11 in total

1.  Characterization of a nicotinic acetylcholine receptor from rabbit skeletal muscle and reconstitution in planar phospholipid bilayers.

Authors:  R J Bradley; J H Howell; W O Romine; G F Carl; G E Kemp
Journal:  Biochem Biophys Res Commun       Date:  1976-01-26       Impact factor: 3.575

2.  Single ionic channels induced in lipid bilayers by polyene antibiotics amphotericin B and nystatine.

Authors:  L N Ermishkin; K M Kasumov; V M Potzeluyev
Journal:  Nature       Date:  1976-08-19       Impact factor: 49.962

Review 3.  Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems.

Authors:  D A Haydon; S B Hladky
Journal:  Q Rev Biophys       Date:  1972-05       Impact factor: 5.318

Review 4.  Membrane noise.

Authors:  A A Verveen; L J DeFelice
Journal:  Prog Biophys Mol Biol       Date:  1974       Impact factor: 3.667

5.  The structure and function of amphotericin B-cholesterol pores in lipid bilayer membranes.

Authors:  T E Andreoli
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

6.  The effects of the polyene antibiotics nystatin and amphotericin B on thin lipid membranes.

Authors:  R W Holz
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

7.  Discreteness of conductance change in bimolecular lipid membranes in the presence of certain antibiotics.

Authors:  S B Hladky; D A Haydon
Journal:  Nature       Date:  1970-01-31       Impact factor: 49.962

8.  Single channel conductance at lipid bilayer membranes in presence of monazomycin.

Authors:  E Bamberg; K Janko
Journal:  Biochim Biophys Acta       Date:  1976-03-19

9.  Membrane excitation through voltage-induced aggregation of channel precursors.

Authors:  P Mueller
Journal:  Ann N Y Acad Sci       Date:  1975-12-30       Impact factor: 5.691

10.  Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes.

Authors:  B de Kruijff; R A Demel
Journal:  Biochim Biophys Acta       Date:  1974-02-26
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  3 in total

1.  Effect of membrane structure on the action of polyenes: I. Nystatin action in cholesterol- and ergosterol-containing membranes.

Authors:  K S Récamier; A Hernández-Gómez; J González-Damián; I Ortega-Blake
Journal:  J Membr Biol       Date:  2010-09-26       Impact factor: 1.843

2.  Effect of membrane structure on the action of polyenes II: nystatin activity along the phase diagram of ergosterol- and cholesterol-containing POPC membranes.

Authors:  J González-Damián; I Ortega-Blake
Journal:  J Membr Biol       Date:  2010-09-25       Impact factor: 1.843

Review 3.  1/f noise in membranes.

Authors:  B Neumcke
Journal:  Biophys Struct Mech       Date:  1978-07-12
  3 in total

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