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Literature DB >> 8435480

The nude mouse as an in vivo model for human breast cancer invasion and metastasis.

N Brünner¹, B Boysen, J Rømer, M Spang-Thomsen.

Abstract

Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.

Entities: Disease Gene Species

Mesh：

Substances：
Genetic Markers

Year: 1993 PMID： 8435480 DOI： 10.1007/bf01833265

Source DB: PubMed Journal: Breast Cancer Res Treat ISSN： 0167-6806 Impact factor: 4.872

26 in total

1. Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors.

Authors: X Xie; N Brünner; G Jensen; J Albrectsen; B Gotthardsen; J Rygaard
Journal: Clin Exp Metastasis Date: 1992-05 Impact factor: 5.150

2. Heterotransplantation of a human malignant tumour to "Nude" mice.

Authors: J Rygaard; C O Povlsen
Journal: Acta Pathol Microbiol Scand Date: 1969

3. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

Authors: G P Nolan; S Fiering; J F Nicolas; L A Herzenberg
Journal: Proc Natl Acad Sci U S A Date: 1988-04 Impact factor: 11.205

Review 4. Endocrine therapy of human breast cancer grown in nude mice.

Authors: N Brünner; C K Osborne; M Spang-Thomsen
Journal: Breast Cancer Res Treat Date: 1987-12 Impact factor: 4.872

5. The use of a genotypic marker to demonstrate clonal dominance during the growth and metastasis of a human breast carcinoma in nude mice.

Authors: J E Price; C Bell; P Frost
Journal: Int J Cancer Date: 1990-05-15 Impact factor: 7.396

6. Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

Authors: R Clarke; N Brünner; B S Katzenellenbogen; E W Thompson; M J Norman; C Koppi; S Paik; M E Lippman; R B Dickson
Journal: Proc Natl Acad Sci U S A Date: 1989-05 Impact factor: 11.205

7. lacZ transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis.

Authors: N Brünner; E W Thompson; M Spang-Thomsen; J Rygaard; K Danø; J A Zwiebel
Journal: Eur J Cancer Date: 1992 Impact factor: 9.162

8. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines.

Authors: E W Thompson; S Paik; N Brünner; C L Sommers; G Zugmaier; R Clarke; T B Shima; J Torri; S Donahue; M E Lippman
Journal: J Cell Physiol Date: 1992-03 Impact factor: 6.384

9. Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection.

Authors: R S Kerbel; C Waghorne; M S Man; B Elliott; M L Breitman
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

Review 10. Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites.

Authors: G L Nicolson
Journal: Cancer Metastasis Rev Date: 1988-06 Impact factor: 9.264

13 in total

1. Expression of molecular biomarkers in primary breast tumors implanted into a surrogate host: increased levels of cyclins correlate with tumor progression.

Authors: G Wani; I Noyes; G E Milo; S M D'Ambrosio
Journal: Mol Med Date: 1997-04 Impact factor: 6.354

Review 2. Technical considerations for studying cancer metastasis in vivo.

Authors: D R Welch
Journal: Clin Exp Metastasis Date: 1997-05 Impact factor: 5.150

3. Influence of antiestrogens on the migration of breast cancer cells using an in vitro wound model.

Authors: A C Mathew; T T Rajah; G M Hurt; S M Abbas Abidi; J J Dmytryk; J T Pento
Journal: Clin Exp Metastasis Date: 1997-07 Impact factor: 5.150

4. Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.

Authors: D Couissi; V Dubois; C Remacle; E Schonne; A Trouet
Journal: Clin Exp Metastasis Date: 1997-07 Impact factor: 5.150

5. Effect of MRC-5 fibroblast conditioned medium on breast cancer cell motility and invasion in vitro.

Authors: N Heylen; R Baurain; C Remacle; A Trouet
Journal: Clin Exp Metastasis Date: 1998-02 Impact factor: 5.150

Review 6. Reporter genes in transgenic mice.

Authors: C Cui; M A Wani; D Wight; J Kopchick; P J Stambrook
Journal: Transgenic Res Date: 1994-05 Impact factor: 2.788