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Literature DB >> 8435373

Renal and extrarenal sites of action of diuretics.

G Giebisch¹, G Klein-Robbenhaar, J Klein-Robbenhaar, K Ratheiser, R Unwin.

Abstract

This paper provides (a) a survey of the basic tubule transport mechanisms of sodium and potassium ions along the nephron, (b) a comparison of the overall renal effects of two diuretic agents (torasemide and furosemide), as assessed by renal clearance techniques, (c) an analysis of the tubule sites of action of torasemide evaluated by free-flow micropuncture and microperfusion techniques, and (d) a brief evaluation of some extrarenal transport effects of loop diuretics.

Entities: Chemical

Mesh：

Substances：

Year: 1993 PMID： 8435373 DOI： 10.1007/bf00877954

Source DB: PubMed Journal: Cardiovasc Drugs Ther ISSN： 0920-3206 Impact factor: 3.727

30 in total

Review 1. The renal proximal tubule: a model for diversity of anion exchangers and stilbene-sensitive anion transporters.

Authors: P S Aronson
Journal: Annu Rev Physiol Date: 1989 Impact factor: 19.318

Review 2. Adrenal corticosteroid action on the thick ascending limb.

Authors: P Dietl; D Good; B Stanton
Journal: Semin Nephrol Date: 1990-07 Impact factor: 5.299

3. Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule.

Authors: L G Palmer; G Frindt
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

4. Active absorption of NH4+ by rat medullary thick ascending limb: inhibition by potassium.

Authors: D W Good
Journal: Am J Physiol Date: 1988-07

5. Tubular action of diuretics: distal effects on electrolyte transport and acidification.

Authors: M Hropot; N Fowler; B Karlmark; G Giebisch
Journal: Kidney Int Date: 1985-09 Impact factor: 10.612

6. Cellular Mechanism of the furosemide sensitive transport system in the kidney.

Authors: H Oberleithner; G Giebisch; F Lang; W Wang
Journal: Klin Wochenschr Date: 1982-10-01

7. Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport.

Authors: P Silva; J Stoff; M Field; L Fine; J N Forrest; F H Epstein
Journal: Am J Physiol Date: 1977-10

Review 8. Potassium-sparing diuretics.

Authors: J D Horisberger; G Giebisch
Journal: Ren Physiol Date: 1987

4. Determining the effectiveness of torasemide and furosemide in heart failure: design of a randomised comparison using the regenstrief medical record system.

Authors: M D Murray; W M Tierney; D C Brater
Journal: Clin Drug Investig Date: 1998 Impact factor: 2.859

4 in total

Renal and extrarenal sites of action of diuretics.

Review 1. The renal proximal tubule: a model for diversity of anion exchangers and stilbene-sensitive anion transporters.

Review 2. Adrenal corticosteroid action on the thick ascending limb.

3. Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule.

4. Active absorption of NH4+ by rat medullary thick ascending limb: inhibition by potassium.

5. Tubular action of diuretics: distal effects on electrolyte transport and acidification.

6. Cellular Mechanism of the furosemide sensitive transport system in the kidney.

7. Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport.

Review 8. Potassium-sparing diuretics.

9. ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney.

10. Relationship between cell volume and ion transport in the early distal tubule of the Amphiuma kidney.

Review 1. Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction.

2. Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion.

Review 3. Benefits and risks of torasemide in congestive heart failure and essential hypertension.

4. Determining the effectiveness of torasemide and furosemide in heart failure: design of a randomised comparison using the regenstrief medical record system.