Literature DB >> 8434637

Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid.

F M van den Berg1, I O Baas, M M Polak, G J Offerhaus.   

Abstract

With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival paraffin-embedded tissue samples of colon, stomach, and pancreas neoplasms. Using monoclonal anti-p53 antibody pAb1801 as well as polyclonal antiserum to p53 CM1, TUF-mediated immunohistochemistry was fully concordant for p53 overexpression in paraffin-embedded carcinoma samples compared with freshly frozen tissue from the same tumors. Thus, prognostic and diagnostic assessment of p53 overexpression in malignant tissue, routinely fixed in formalin and embedded in paraffin wax, by TUF-mediated immunohistochemistry with monoclonal and polyclonal antibodies may be adopted as a new tool in diagnostic and research histopathology.

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Year:  1993        PMID： 8434637      PMCID： PMC1886719     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  17 in total

1.  Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections.

Authors:  S R Shi; M E Key; K L Kalra
Journal:  J Histochem Cytochem       Date:  1991-06       Impact factor: 2.479

Review 2.  Molecular themes in oncogenesis.

Authors:  J M Bishop
Journal:  Cell       Date:  1991-01-25       Impact factor: 41.582

Review 3.  A genetic model for colorectal tumorigenesis.

Authors:  E R Fearon; B Vogelstein
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

4.  Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.

Authors:  J H Kim; T Takahashi; I Chiba; J G Park; M J Birrer; J K Roh; H De Lee; J P Kim; J D Minna; A F Gazdar
Journal:  J Natl Cancer Inst       Date:  1991-07-03       Impact factor: 13.506

5.  p53 mutations in colorectal cancer.

Authors:  N R Rodrigues; A Rowan; M E Smith; I B Kerr; W F Bodmer; J V Gannon; D P Lane
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

6.  p53 expression in colorectal tumors.

Authors:  C A Purdie; J O'Grady; J Piris; A H Wyllie; C C Bird
Journal:  Am J Pathol       Date:  1991-04       Impact factor: 4.307

7.  p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

Authors:  Y Yamada; T Yoshida; K Hayashi; T Sekiya; J Yokota; S Hirohashi; K Nakatani; H Nakano; T Sugimura; M Terada
Journal:  Cancer Res       Date:  1991-11-01       Impact factor: 12.701

8.  Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

Authors:  J Caamano; B Ruggeri; S Momiki; A Sickler; S Y Zhang; A J Klein-Szanto
Journal:  Am J Pathol       Date:  1991-10       Impact factor: 4.307

9.  Expression of the nuclear oncogene p53 in colon tumours.

Authors:  F M van den Berg; A J Tigges; M E Schipper; F C den Hartog-Jager; W G Kroes; J M Walboomers
Journal:  J Pathol       Date:  1989-03       Impact factor: 7.996

10.  Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas.

Authors:  E Campo; O de la Calle-Martin; R Miquel; A Palacin; M Romero; V Fabregat; J Vives; A Cardesa; J Yague
Journal:  Cancer Res       Date:  1991-08-15       Impact factor: 12.701
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  23 in total

1.  Keratin antigen retrieval in oral mucosal biopsies using microwave processing.

Authors:  G R Ogden; D Lunny; E B Lane
Journal:  Histochem J       Date:  1996-12

2.  Immunohistochemistry of whole-organ sections of advanced human laryngeal cancer.

Authors:  Claus Wittekindt; Christian Sittel; Hans Michael Kvasnicka; Hans Edmund Eckel
Journal:  Eur Arch Otorhinolaryngol       Date:  2006-05-09       Impact factor: 2.503

3.  Leptomeningeal melanomatosis with multiple cutaneous pigmented nevi: tumor cell proliferation and malignant transformation in an autopsy case.

Authors:  H Oka; T Kameya; T Hata; N Kawano; K Fujii; K Yada
Journal:  J Neurooncol       Date:  1999-08       Impact factor: 4.130

4.  Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.

Authors:  R P Bruyn; J H Koelman; D Troost; J M de Jong
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-06       Impact factor: 10.154

5.  Relationship between CD44 expression and cell proliferation in epithelium and stroma of colorectal neoplasms.

Authors:  K Furuta; M Zahurak; X L Yang; C Rosada; S N Goodman; J T August; S R Hamilton
Journal:  Am J Pathol       Date:  1996-10       Impact factor: 4.307

6.  Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

Authors:  H Kim; J Jen; B Vogelstein; S R Hamilton
Journal:  Am J Pathol       Date:  1994-07       Impact factor: 4.307

7.  Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.

Authors:  J A DiGiuseppe; R H Hruban; G J Offerhaus; M J Clement; F M van den Berg; J L Cameron; A D van Mansfeld
Journal:  Am J Pathol       Date:  1994-05       Impact factor: 4.307

8.  Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma.

Authors:  H Kitamura; Y Kameda; N Nakamura; Y Nakatani; Y Inayama; M Iida; K Noda; N Ogawa; T Shibagaki; M Kanisawa
Journal:  Am J Pathol       Date:  1995-04       Impact factor: 4.307

9.  p53 protein overexpression as a predictor of the response to chemotherapy in gastric cancer.

Authors:  B Nakata; K H Chung; M Ogawa; Y Ogawa; K Yanagawa; K Muguruma; T Inoue; Y Yamashita; N Onoda; K Maeda; T Sawada; M Sowa
Journal:  Surg Today       Date:  1998       Impact factor: 2.549

10.  Immunohistochemical detection of p53 protein in cutaneous lesions from transplant recipients harbouring human papillomavirus DNA.

Authors:  I Pélisson; Y Chardonnet; S Euvrard; D Schmitt
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064
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