Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization.

A cDNA clone encoding the human polyadenylate-binding protein (PABP) was isolated and mapped to the genome by in situ hybridization. The cDNA was found to bind preferentially to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13. In addition, Southern blot analysis of genomic DNA using a PABP cDNA probe revealed a complex pattern of bands. The results indicate that PABP belongs to a multigene family of related sequences.