J V Diengdoh1, M D Shaw. 1. Department of Neuropathology, Walton Centre for Neurology and Neurosurgery, Walton Hospital, Liverpool, United Kingdom.
Abstract
BACKGROUND: The case of a left temporoparietal choroid plexus papilloma in a 12-year-old girl, which recurred 12 months after subtotal resection and apparent full recovery, is described. METHODS: The two consecutive surgical specimens were studied by light and electron microscopy. RESULTS: The first surgical specimen showed a tumor composed of cells with distended cytoplasm packed with numerous mitochondria characteristic of "oncocytic" change. Thus, tumor was the rare benign oncocytic variant of choroid plexus papilloma. A repeat histologic study of the recurrent tumor 12 months later showed evidence of malignant evolution in the form of multinucleated cells with frequent, often bizarre, mitotic figures. CONCLUSION: A rarely described oncocytic variant of choroid plexus papilloma that showed evidence of evolution from benign to malignant "oncocytoma" is discussed.
BACKGROUND: The case of a left temporoparietal choroid plexus papilloma in a 12-year-old girl, which recurred 12 months after subtotal resection and apparent full recovery, is described. METHODS: The two consecutive surgical specimens were studied by light and electron microscopy. RESULTS: The first surgical specimen showed a tumor composed of cells with distended cytoplasm packed with numerous mitochondria characteristic of "oncocytic" change. Thus, tumor was the rare benign oncocytic variant of choroid plexus papilloma. A repeat histologic study of the recurrent tumor 12 months later showed evidence of malignant evolution in the form of multinucleated cells with frequent, often bizarre, mitotic figures. CONCLUSION: A rarely described oncocytic variant of choroid plexus papilloma that showed evidence of evolution from benign to malignant "oncocytoma" is discussed.