Literature DB >> 8431404

Postmortem concentrations of thiopental in tissues: a sudden death case.

T Yasuda1, T Yamaba, K Sawazaki, F Masuyama, D Nadano, H Takeshita, K Kishi.   

Abstract

High-performance liquid chromatography was employed to determine the concentration of thiopental in body fluids and tissues in an individual who had died due to intravenous injection of the clinical dose. The blood concentration of thiopental was 0.6 mg/l. Among the 10 tissues examined, the brain and thymus showed the highest level of the drug; 11.9 mg/kg and 7.66 mg/kg, respectively. The results are discussed in the light of the relevant literature.

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Year:  1993        PMID: 8431404     DOI: 10.1007/bf01642801

Source DB:  PubMed          Journal:  Int J Legal Med        ISSN: 0937-9827            Impact factor:   2.686


  8 in total

1.  A suicide by thiopentone infusion.

Authors:  G C Fernando
Journal:  Am J Forensic Med Pathol       Date:  1990-12       Impact factor: 0.921

2.  Thiamylal: review of the literature and report of a suicide.

Authors:  A G Costantino; Y H Caplan; B S Levine; A M Dixon; J E Smialek
Journal:  J Forensic Sci       Date:  1990-01       Impact factor: 1.832

3.  Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry.

Authors:  K Kudo; T Nagata; K Kimura; R Uehori; M Noda
Journal:  Forensic Sci Int       Date:  1988-05       Impact factor: 2.395

4.  Thiamylal anaphylaxis.

Authors:  D S Thompson; C N Eason; J W Flacke
Journal:  Anesthesiology       Date:  1973-11       Impact factor: 7.892

5.  Estimation of plasma thiopentone. The use of high performance liquid chromatography and an ether extraction.

Authors:  W Toner; P J Howard; J W Dundee; P D McIlroy
Journal:  Anaesthesia       Date:  1979 Jul-Aug       Impact factor: 6.955

6.  Analysis of thiopentone in human plasma by high-performance liquid chromatography.

Authors:  G L Blackman; G J Jordan
Journal:  J Chromatogr       Date:  1978-05-01

7.  Reversed-phase liquid-chromatographic simultaneous analysis for thiopental and pentobarbital in serum.

Authors:  M Kelner; D N Bailey
Journal:  Clin Chem       Date:  1983-06       Impact factor: 8.327

8.  Adverse reactions to intravenous anaesthetics.

Authors:  R S Clarke; J w Dundee; F T Garrett; G K McArdle; J A Sutton
Journal:  Br J Anaesth       Date:  1975-05       Impact factor: 9.166

  8 in total
  2 in total

Review 1.  Pharmacodynamics and pharmacokinetics of thiopental.

Authors:  H Russo; F Bressolle
Journal:  Clin Pharmacokinet       Date:  1998-08       Impact factor: 6.447

2.  Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.

Authors:  Christian I Schwer; Cornelius Lehane; Timo Guelzow; Simone Zenker; Karl M Strosing; Sashko Spassov; Anika Erxleben; Bernd Heimrich; Hartmut Buerkle; Matjaz Humar
Journal:  PLoS One       Date:  2013-10-22       Impact factor: 3.240

  2 in total

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