Hypertension of aortic coarctation: the role of renal and other factors.

In order to establish the relationship between the renal and other factors associated with the hypertension of coarctation of the aorta, aortic strictures were created in two groups of adult dogs (Groups A and B). Group B in addition had transference of total renal blood flow proximal to the stricture to eliminate the renal aspects of the hypertension. Carotid and femoral artery pressures were measured at monthly intervals for 24 weeks. Group A developed progressive generalised hypertension while Group B only developed hypertension proximal to the coarctation. The dominant role of a renal factor producing a generalised vascular response is confirmed, the localised proximal hypertension in Group B reflecting the mechanical obstruction imposed by the aortic stricture. There is no evidence to suggest that other organs distal to the coarctation are implicated in the development of arterial hypertension.