OBJECTIVE: To examine synchronous changes in soluble interleukin-2 receptor (sIL-2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA). METHODS: Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL-2R. Pooled within-person correlations among these variables were calculated. RESULTS: Consistent with the results of previous research, joint inflammation covaried directly with sIL-2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL-2R levels and increases in reported joint pain. CONCLUSION: These findings provide preliminary evidence that psychoimmune processes may be implicated in short-term changes in RA disease activity.
OBJECTIVE: To examine synchronous changes in soluble interleukin-2 receptor (sIL-2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA). METHODS: Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL-2R. Pooled within-person correlations among these variables were calculated. RESULTS: Consistent with the results of previous research, joint inflammation covaried directly with sIL-2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL-2R levels and increases in reported joint pain. CONCLUSION: These findings provide preliminary evidence that psychoimmune processes may be implicated in short-term changes in RA disease activity.
Authors: A G van de Langerijt; P L van Lent; A R Hermus; C G Sweep; A R Cools; W B van den Berg Journal: Clin Exp Immunol Date: 1994-07 Impact factor: 4.330
Authors: J Hayashi; Y Kishihara; K Yamaji; E Yoshimura; M Ohmiya; Y Tani; H Ikematsu; S Kashiwagi Journal: Dig Dis Sci Date: 1995-08 Impact factor: 3.199
Authors: Y Sawayama; J Hayashi; Y Kawakami; N Furusyo; I Ariyama; Y Kishihara; K Ueno; S Kashiwagi Journal: Dig Dis Sci Date: 1999-01 Impact factor: 3.199
Authors: Sabine J M de Brouwer; Floris W Kraaimaat; Fred C G J Sweep; Marjonne C W Creemers; Timothy R D J Radstake; Antoinette I M van Laarhoven; Piet L C M van Riel; Andrea W M Evers Journal: Arthritis Res Ther Date: 2010-05-17 Impact factor: 5.156