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Literature DB >> 8430781

Estimation of protein fractional synthetic rate from tracer data.

Abstract

The fractional synthetic rate (FSR) is a key parameter characterizing protein turnover that is estimated from tracer kinetic data. Formulas to estimate this parameter usually assume a precursor-product model. Assuming this model is correct, we discuss these formulas to estimate the FSR in the steady and non-steady state both for the radioactive and stable isotope tracer. Then we deal with the non-steady-state case where the FSR becomes time varying and derive formulas for its estimation. A non-steady-state case study on the flooding-dose technique for measuring protein turnover is presented.

Mesh：

Substances：
Isotopes

Year: 1993 PMID： 8430781 DOI： 10.1152/ajpendo.1993.264.1.E128

Source DB: PubMed Journal: Am J Physiol ISSN： 0002-9513

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Cited

15 in total

1. An alternative cytokinin biosynthesis pathway.

Authors: C Astot; K Dolezal; A Nordström; Q Wang; T Kunkel; T Moritz; N H Chua; G Sandberg
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

2. Alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins.

Authors: Rajasekhar Ramakrishnan
Journal: Metabolism Date: 2007-11 Impact factor: 8.694

3. Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics.

Authors: Elena Volpi; David L Chinkes; Blake B Rasmussen
Journal: Am J Physiol Endocrinol Metab Date: 2008-08-19 Impact factor: 4.310

10. Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism.

Authors: S Fujita; E L Glynn; K L Timmerman; B B Rasmussen; E Volpi
Journal: Diabetologia Date: 2009-07-09 Impact factor: 10.122

Estimation of protein fractional synthetic rate from tracer data.

1. An alternative cytokinin biosynthesis pathway.

2. Alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins.

3. Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics.

4. Measuring proteome dynamics in vivo: as easy as adding water?

5. Basal muscle intracellular amino acid kinetics in women and men.

6. Effect of elective abdominal surgery on human colon protein synthesis in situ.

Review 7. Neonatal polyunsaturated fatty acid metabolism.

8. Nutrition and sarcopenia of ageing.

9. Nutrient signalling in the regulation of human muscle protein synthesis.

10. Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism.