A sign for the early detection of medullary sclerosis.

The radiographic image of a normal bone has a continuous radiopaque boundary of variable thickness and a relatively radiolucent interior. Normally, the endosteal edge of this boundary line is well defined. However, this edge may be obscured in diseases that induce medullary new bone formation. The use of this sign for the early detection of medullary sclerosis is demonstrated by specific examples.