| Literature DB >> 8429340 |
J D Kelly1, A M Forster, B Higley, C M Archer, F S Booker, L R Canning, K W Chiu, B Edwards, H K Gill, M McPartlin.
Abstract
A new cationic complex, [99mTc(tetrofosmin)2O2]+, where tetrofosmin is the ether functionalized diphosphine ligand 1,2-bis[bis(2-ethoxyethyl)phosphino]ethane, has been synthesized and evaluated for potential use in myocardial perfusion imaging. The structure of the complex has been determined by x-ray crystallography of the 99Tc analog. In comparison with previously reported 99mTc complexes of alkyl-phosphines, the tetrofosmin species shows substantially increased clearance from nontarget tissue, especially blood and liver. A freeze-dried kit formulation has been developed. The kit provides a product of high radiochemical purity up to 8 hr after reconstitution at room temperature.Entities:
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Year: 1993 PMID： 8429340
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057