Literature DB >> 8428394

Cytokine-induced inhibition of Plasmodium falciparum erythrocytic growth in vitro.

A S Orago1, C A Facer.   

Abstract

The addition of recombinant cytokines to Plasmodium falciparum in vitro cultures retarded the growth of the parasite with the effect of recombinant IL-2 (rIL-2) > interferon-gamma (IFN-gamma) > tumour necrosis factor-beta (TNF-beta). The process was concentration dependent, being greatest at 30,000 U/ml and required a 72-h period of continuous exposure for maximum effect. Growth inhibition, as determined morphologically and radiometrically, was a consequence of defective schizont maturation rather than inhibition of merozoite invasion. It was cumulative and detectable within one erythrocytic (48 h) growth cycle.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8428394      PMCID： PMC1554667          DOI： 10.1111/j.1365-2249.1993.tb05897.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  24 in total

1.  Synthesis of adenosine nucleotides from hypoxanthine by human malaria parasites (Plasmodium falciparum) in continuous erythrocyte culture: inhibition by hadacidin but not alanosine.

Authors:  H K Webster; J M Whaun; M D Walker; T L Bean
Journal:  Biochem Pharmacol       Date:  1984-05-01       Impact factor: 5.858

2.  Protein and nucleic acid synthesis during synchronized growth of Plasmodium falciparum.

Authors:  C A Gritzmacher; R T Reese
Journal:  J Bacteriol       Date:  1984-12       Impact factor: 3.490

3.  Recombinant tumour necrosis factor inhibits malaria parasites in vivo but not in vitro.

Authors:  J Taverne; J Tavernier; W Fiers; J H Playfair
Journal:  Clin Exp Immunol       Date:  1987-01       Impact factor: 4.330

4.  Tumour necrosis factor-dependent parasite-killing effects during paroxysms in non-immune Plasmodium vivax malaria patients.

Authors:  N D Karunaweera; R Carter; G E Grau; D Kwiatkowski; G Del Giudice; K N Mendis
Journal:  Clin Exp Immunol       Date:  1992-06       Impact factor: 4.330

5.  Tumour necrosis factor induction by malaria exoantigens depends upon phospholipid.

Authors:  C A Bate; J Taverne; E Román; C Moreno; J H Playfair
Journal:  Immunology       Date:  1992-01       Impact factor: 7.397

6.  The role of T lymphocytes in immunity to Plasmodium falciparum. Enhancement of neutrophil-mediated parasite killing by lymphotoxin and IFN-gamma: comparisons with tumor necrosis factor effects.

Authors:  L M Kumaratilake; A Ferrante; C Rzepczyk
Journal:  J Immunol       Date:  1991-01-15       Impact factor: 5.422

7.  TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria.

Authors:  D Kwiatkowski; A V Hill; I Sambou; P Twumasi; J Castracane; K R Manogue; A Cerami; D R Brewster; B M Greenwood
Journal:  Lancet       Date:  1990-11-17       Impact factor: 79.321

8.  Association between human serum-induced crisis forms in cultured Plasmodium falciparum and clinical immunity to malaria in Sudan.

Authors:  J B Jensen; M T Boland; J S Allan; J M Carlin; J A Vande Waa; A A Divo; M A Akood
Journal:  Infect Immun       Date:  1983-09       Impact factor: 3.441

9.  Stage- and time-dependent effects of crisis form factor on Plasmodium falciparum in vitro.

Authors:  J M Carlin; J B Jensen
Journal:  J Parasitol       Date:  1986-12       Impact factor: 1.276

10.  Cytotoxicity of human natural killer (NK) cell subsets for Plasmodium falciparum erythrocytic schizonts: stimulation by cytokines and inhibition by neomycin.

Authors:  A S Orago; C A Facer
Journal:  Clin Exp Immunol       Date:  1991-10       Impact factor: 4.330
View more
  2 in total

1.  Decreased serum levels of TGF-beta in patients with acute Plasmodium falciparum malaria.

Authors:  C Wenisch; B Parschalk; H Burgmann; S Looareesuwan; W Graninger
Journal:  J Clin Immunol       Date:  1995-03       Impact factor: 8.317

2.  Erythrocytes carrying mutations in spectrin and protein 4.1 show differing sensitivities to invasion by Plasmodium falciparum.

Authors:  C A Facer
Journal:  Parasitol Res       Date:  1995       Impact factor: 2.289
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.