Literature DB >> 8428352

Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine.

S G Carmella1, S Akerkar, S S Hecht.   

Abstract

Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 micrograms/24 h, respectively. The results of this study provide the first evidence for metabolites of tobacco-specific nitrosamines in human urine.

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Year:  1993        PMID： 8428352

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  25 in total

Review 1.  Biomarkers to assess the utility of potential reduced exposure tobacco products.

Authors:  Dorothy K Hatsukami; Neal L Benowitz; Stephen I Rennard; Cheryl Oncken; Stephen S Hecht
Journal:  Nicotine Tob Res       Date:  2006-08       Impact factor: 4.244

Review 2.  Biomarkers of exposure to new and emerging tobacco delivery products.

Authors:  Suzaynn F Schick; Benjamin C Blount; Peyton Jacob; Najat A Saliba; John T Bernert; Ahmad El Hellani; Peter Jatlow; R Steven Pappas; Lanqing Wang; Jonathan Foulds; Arunava Ghosh; Stephen S Hecht; John C Gomez; Jessica R Martin; Clementina Mesaros; Sanjay Srivastava; Gideon St Helen; Robert Tarran; Pawel K Lorkiewicz; Ian A Blair; Heather L Kimmel; Claire M Doerschuk; Neal L Benowitz; Aruni Bhatnagar
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2017-05-18       Impact factor: 5.464

3.  Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice.

Authors:  Manohar Puppala; Sreekanth C Narayanapillai; Pablo Leitzman; Haifeng Sun; Pramod Upadhyaya; M Gerard O'Sullivan; Stephen S Hecht; Chengguo Xing
Journal:  J Med Chem       Date:  2017-09-13       Impact factor: 7.446

Review 4.  Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators.

Authors:  Samir S Khariwala; Dorothy Hatsukami; Stephen S Hecht
Journal:  Head Neck       Date:  2011-05-25       Impact factor: 3.147

5.  The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers.

Authors:  Yi Wang; Sreekanth C Narayanapillai; Katelyn M Tessier; Lori G Strayer; Pramod Upadhyaya; Qi Hu; Rick Kingston; Ramzi G Salloum; Junxuan Lu; Stephen S Hecht; Dorothy K Hatsukami; Naomi Fujioka; Chengguo Xing
Journal:  Cancer Prev Res (Phila)       Date:  2020-02-26

6.  It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco.

Authors:  Stephen S Hecht
Journal:  Cancer Prev Res (Phila)       Date:  2014-05-07

7.  Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers.

Authors:  Gang Chen; Shaman Luo; Shannon Kozlovich; Philip Lazarus
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-05-09       Impact factor: 4.254

8.  Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.

Authors:  Sreekanth C Narayanapillai; Linda B von Weymarn; Steven G Carmella; Pablo Leitzman; Jordan Paladino; Pramod Upadhyaya; Stephen S Hecht; Sharon E Murphy; Chengguo Xing
Journal:  Drug Metab Dispos       Date:  2016-01-07       Impact factor: 3.922

9.  Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users.

Authors:  Delshanee Kotandeniya; Steven G Carmella; Makenzie E Pillsbury; Stephen S Hecht
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2015-10-31       Impact factor: 3.205

10.  Metabolism of a glucuronide conjugate of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats.

Authors:  S E Atawodi; K Michelsen; E Richter
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153
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