| Literature DB >> 8428133 |
G I Hurowitz1, J M Silver, M F Brin, D T Williams, W G Johnson.
Abstract
Deficiency of hexosaminidase A causes the GM2 gangliosidosis known as Tay-Sachs disease. It is now known that this condition has several late-onset variants that cause numerous neuropsychiatric disturbances. Early recognition is important because treatment with phenothiazines and heterocyclic antidepressants may worsen the course. The authors report two cases with several new findings, including prominent psychiatric symptoms without psychosis early in the course of the illness.Entities:
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Year: 1993 PMID： 8428133 DOI： 10.1176/jnp.5.1.30
Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198