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Literature DB >> 8427782

Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.

R Dittadi¹, P M Donisi, A Brazzale, L Cappellozza, G Bruscagnin, M Gion.

Abstract

Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.

Entities: Disease Gene

Mesh：

Substances：

Year: 1993 PMID： 8427782 PMCID： PMC1968236 DOI： 10.1038/bjc.1993.2

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

10 in total

1. Hydroxyapatite assay to measure epidermal growth factor receptor in human primary breast tumors.

Authors: T J Benraad; J A Foekens
Journal: Ann Clin Biochem Date: 1990-05 Impact factor: 2.057

2. Immunohistochemical studies on oncogene products (c-erbB-2, EGFR, c-myc) and estrogen receptor in benign and malignant breast lesions. With special reference to their prognostic significance in carcinoma.

Authors: K Tauchi; S Hori; H Itoh; R Y Osamura; Y Tokuda; T Tajima
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1989

3. Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

Authors: F Pekonen; S Partanen; T Mäkinen; E M Rutanen
Journal: Cancer Res Date: 1988-03-01 Impact factor: 12.701

4. Expression of epidermal growth factor receptor in benign and malignant primary tumours of the breast.

Authors: P Möller; G Mechtersheimer; M Kaufmann; G Moldenhauer; F Momburg; T Mattfeldt; H F Otto
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1989

5. Radioligand binding assay of epidermal growth factor receptor: causes of variability and standardization of the assay.

Authors: R Dittadi; M Gion; A Brazzale; G Bruscagnin
Journal: Clin Chem Date: 1990-06 Impact factor: 8.327

6. Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues.

Authors: I Damjanov; B Mildner; B B Knowles
Journal: Lab Invest Date: 1986-11 Impact factor: 5.662

7. Epidermal growth factor receptor-negative tumors are predominantly confined to the subgroup of estradiol receptor-positive human primary breast cancers.

Authors: P G Koenders; L V Beex; A Geurts-Moespot; J J Heuvel; C B Kienhuis; T J Benraad
Journal: Cancer Res Date: 1991-09-01 Impact factor: 12.701

8. neu oncogene protein and epidermal growth factor receptor are independently expressed in benign and malignant breast tissues.

Authors: Y Tsutsumi; S P Naber; R A DeLellis; H J Wolfe; P J Marks; S J McKenzie; S Yin
Journal: Hum Pathol Date: 1990-07 Impact factor: 3.466

9. Epidermal growth factor receptor and oestrogen receptors in the non-malignant part of the cancerous breast.

Authors: S Barker; C Panahy; J R Puddefoot; A W Goode; G P Vinson
Journal: Br J Cancer Date: 1989-11 Impact factor: 7.640

10. Epidermal growth factor receptors in cancer tissues of esophagus, lung, pancreas, colorectum, breast and stomach.

Authors: S Ozawa; M Ueda; N Ando; O Abe; N Shimizu
Journal: Jpn J Cancer Res Date: 1988-11

10 in total

11 in total

1. Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells.

Authors: D K Biswas; A P Cruz; E Gansberger; A B Pardee
Journal: Proc Natl Acad Sci U S A Date: 2000-07-18 Impact factor: 11.205

10. Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand-binding assay and clinical relevance in breast cancer.

Authors: J C Newby; R P A'Hern; R D Leek; I E Smith; A L Harris; M Dowsett
Journal: Br J Cancer Date: 1995-06 Impact factor: 7.640

Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.

1. Hydroxyapatite assay to measure epidermal growth factor receptor in human primary breast tumors.

2. Immunohistochemical studies on oncogene products (c-erbB-2, EGFR, c-myc) and estrogen receptor in benign and malignant breast lesions. With special reference to their prognostic significance in carcinoma.

3. Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

4. Expression of epidermal growth factor receptor in benign and malignant primary tumours of the breast.

5. Radioligand binding assay of epidermal growth factor receptor: causes of variability and standardization of the assay.

6. Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues.

7. Epidermal growth factor receptor-negative tumors are predominantly confined to the subgroup of estradiol receptor-positive human primary breast cancers.

8. neu oncogene protein and epidermal growth factor receptor are independently expressed in benign and malignant breast tissues.

9. Epidermal growth factor receptor and oestrogen receptors in the non-malignant part of the cancerous breast.

10. Epidermal growth factor receptors in cancer tissues of esophagus, lung, pancreas, colorectum, breast and stomach.

1. Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells.

2. Epidermal growth factor receptor and c-erbB-2 expression in normal breast tissue during the menstrual cycle.

Review 3. Hormonal regulation of type I receptor tyrosine kinase expression in the mammary gland.

Review 4. The epidermal growth factor receptor in breast cancer.

5. Conflicting roles of EGFR expression by subtypes in breast cancer.

6. The epidermal growth factor receptor family in breast cancer.

7. Expression of epidermal growth factor receptor (EGFR) in non-affected and tumorous mammary tissue of female dogs.

Review 8. EGF receptor expression, regulation, and function in breast cancer.

Review 9. Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis.

10. Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand-binding assay and clinical relevance in breast cancer.