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Literature DB >> 8427584

Characterization of the promoter of human prostaglandin H synthase-1 gene.

L H Wang¹, A Hajibeigi, X M Xu, D Loose-Mitchell, K K Wu.

Abstract

The gene of human prostaglandin H synthase-1 (PGHS-1,EC 1.14.99.1) was isolated from a human cosmid library and was contained in two overlapping clones. Multiple transcriptional start sites were identified. The major one located 136 bases upstream from the ATG initiation codon. The promoter region contains no canonical TATA box but possesses a high G+C content. These observations suggest that PGHS-1 gene has the characteristics of a housekeeping gene. Both 0.8 and 0.4 kb of the 5'-flanking sequence of the PGHS-1 gene can confer transcriptional activity.

Entities: Chemical Disease Gene Species

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Year: 1993 PMID： 8427584 DOI： 10.1006/bbrc.1993.1062

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

15 in total

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Journal: Prog Lipid Res Date: 2007-01-18 Impact factor: 16.195

2. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.

Authors: M Lasa; K R Mahtani; A Finch; G Brewer; J Saklatvala; A R Clark
Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

3. Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).

Authors: Sandra J Hewett; Jingxue Shi; Yifan Gong; Krishnan Dhandapani; Carol Pilbeam; James A Hewett
Journal: J Biol Chem Date: 2016-11-14 Impact factor: 5.157

4. Transcriptional regulation of cyclooxygenase-2 in the human microvascular endothelial cell line, HMEC-1: control by the combinatorial actions of AP2, NF-IL-6 and CRE elements.

Authors: K Kirtikara; R Raghow; S J Laulederkind; S Goorha; T Kanekura; L R Ballou
Journal: Mol Cell Biochem Date: 2000-01 Impact factor: 3.396

5. Chemoreflex activity increases prostaglandin endoperoxide synthase mRNA expression in the late-gestation fetal sheep brain.

Authors: Melanie J P Fraites; Charles E Wood
Journal: Reprod Sci Date: 2011-09 Impact factor: 3.060

Characterization of the promoter of human prostaglandin H synthase-1 gene.

Review 1. Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.

2. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.

3. Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).

4. Transcriptional regulation of cyclooxygenase-2 in the human microvascular endothelial cell line, HMEC-1: control by the combinatorial actions of AP2, NF-IL-6 and CRE elements.

5. Chemoreflex activity increases prostaglandin endoperoxide synthase mRNA expression in the late-gestation fetal sheep brain.

6. Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).

Review 7. Regulation of prostaglandin synthase-1 and prostaglandin synthase-2.

8. Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma.

9. Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium.

10. Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo.