Literature DB >> 8427408

Human Genome Project.

M P Sawicki1, G Samara, M Hurwitz, E Passaro.   

Abstract

The Human Genome Project is an international effort to clone and sequence the entire human genome. This audacious undertaking, estimated to cost 200 million dollars per year and require 15 years to complete, promises to be one of the most revolutionary and captivating scientific endeavors ever conceived by mankind. By knowing the sequence of the estimated 3 billion base pairs of the haploid human genome and its more than 30,000 genes, many questions will be answered. Moreover, our ability to intervene at the genetic level will be possible. This review outlines the scientific goals and methods of this project and discusses some of its ethical, legal, and social ramifications.

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Year:  1993        PMID： 8427408     DOI： 10.1016/s0002-9610(05)80522-7

Source DB:  PubMed          Journal:  Am J Surg        ISSN： 0002-9610            Impact factor:   2.565


  6 in total

Review 1.  Global trends on fears and concerns of genetic discrimination: a systematic literature review.

Authors:  Annet Wauters; Ine Van Hoyweghen
Journal:  J Hum Genet       Date:  2016-01-07       Impact factor: 3.172

2.  EHR based Genetic Testing Knowledge Base (iGTKB) Development.

Authors:  Qian Zhu; Hongfang Liu; Christopher G Chute; Matthew Ferber
Journal:  BMC Med Inform Decis Mak       Date:  2015-11-25       Impact factor: 2.796

Review 3.  Bile acids at the cross-roads of gut microbiome-host cardiometabolic interactions.

Authors:  Paul M Ryan; Catherine Stanton; Noel M Caplice
Journal:  Diabetol Metab Syndr       Date:  2017-12-28       Impact factor: 3.320

Review 4.  Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases.

Authors:  Yunhui Peng; Emil Alexov; Sankar Basu
Journal:  Int J Mol Sci       Date:  2019-01-28       Impact factor: 5.923

Review 5.  Host and Microbiome Genome-Wide Association Studies: Current State and Challenges.

Authors:  Denis Awany; Imane Allali; Shareefa Dalvie; Sian Hemmings; Kilaza S Mwaikono; Nicholas E Thomford; Andres Gomez; Nicola Mulder; Emile R Chimusa
Journal:  Front Genet       Date:  2019-01-22       Impact factor: 4.599

6.  The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.

Authors:  Abena B Redwood; Xiaomei Zhang; Sahil B Seth; Zhongqi Ge; Wendy E Bindeman; Xinhui Zhou; Vidya C Sinha; Timothy P Heffernan; Helen Piwnica-Worms
Journal:  NPJ Breast Cancer       Date:  2021-12-02
  6 in total

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