Literature DB >> 8425023

Osteoconduction exerted by methylpyrrolidinone chitosan used in dental surgery.

R A Muzzarelli1, G Biagini, M Bellardini, L Simonelli, C Castaldini, G Fratto.   

Abstract

Surgical wounds from wisdom tooth avulsions were medicated with freeze-dried methylpyrrolidinone chitosan, a gel-forming resorbable biopolymer obtained from crab chitosan by chemical modification. Methylpyrrolidinone chitosan promoted osteoconduction and the space left after avulsion was filled with newly formed bone tissue, which conferred desirable mechanical and physiological characteristics to the healed would site. Morphological evidence obtained from biopsies confirmed the radiographic data. Methylpyrrolidinone chitosan was progressively depolymerized by lysozyme and was no longer detected 6 months after surgery. None of the 10 patients reported adverse effects over one year of observation.

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Year:  1993        PMID： 8425023     DOI： 10.1016/0142-9612(93)90073-b

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  28 in total

1.  Stem cell-calcium phosphate constructs for bone engineering.

Authors:  H H K Xu; L Zhao; M D Weir
Journal:  J Dent Res       Date:  2010-10-06       Impact factor: 6.116

2.  Tissue responses to anti-washout apatite cement using chitosan when implanted in the rat tibia.

Authors:  M Takechi; K Ishikawa; Y Miyamoto; M Nagayama; K Suzuki
Journal:  J Mater Sci Mater Med       Date:  2001-07       Impact factor: 3.896

3.  In-situ hardening hydroxyapatite-based scaffold for bone repair.

Authors:  Yu Zhang; Hockin H K Xu; Shozo Takagi; Laurence C Chow
Journal:  J Mater Sci Mater Med       Date:  2006-05       Impact factor: 3.896

4.  Osteophilic multilayer coatings for accelerated bone tissue growth.

Authors:  Nisarg J Shah; Jinkee Hong; Md Nasim Hyder; Paula T Hammond
Journal:  Adv Mater       Date:  2012-02-07       Impact factor: 30.849

5.  Osteogenic media and rhBMP-2-induced differentiation of umbilical cord mesenchymal stem cells encapsulated in alginate microbeads and integrated in an injectable calcium phosphate-chitosan fibrous scaffold.

Authors:  Liang Zhao; Minghui Tang; Michael D Weir; Michael S Detamore; Hockin H K Xu
Journal:  Tissue Eng Part A       Date:  2011-01-04       Impact factor: 3.845

6.  High-strength, in situ-setting calcium phosphate composite with protein release.

Authors:  Michael D Weir; Hockin H K Xu
Journal:  J Biomed Mater Res A       Date:  2008-05       Impact factor: 4.396

7.  Prospective randomized single-blind study of post-operative bleeding after minor oral surgery in patients with cirrhosis.

Authors:  Candan Efeoğlu; Aylin Sipahi Çalış; Zeki Karasu; Hüseyin Koca; Hayal Boyacıoğlu
Journal:  Turk J Gastroenterol       Date:  2019-02       Impact factor: 1.852

8.  Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold.

Authors:  Jennifer L Moreau; Hockin H K Xu
Journal:  Biomaterials       Date:  2009-02-01       Impact factor: 12.479

9.  Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using chitosan and citric acid.

Authors:  Ho-Yeon Song; A H M Esfakur Rahman; Byong-Taek Lee
Journal:  J Mater Sci Mater Med       Date:  2008-12-04       Impact factor: 3.896

Review 10.  Next generation calcium phosphate-based biomaterials.

Authors:  L C Chow
Journal:  Dent Mater J       Date:  2009-01       Impact factor: 2.102
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