Literature DB >> 8423599

Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.

D P Getman1, G A DeCrescenzo, R M Heintz, K L Reed, J J Talley, M L Bryant, M Clare, K A Houseman, J J Marr, R A Mueller.   

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Year:  1993        PMID： 8423599     DOI： 10.1021/jm00054a014

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  17 in total

1.  Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Authors:  William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Wenjuan Ye; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

Review 2.  Antiviral therapy for human immunodeficiency virus infections.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  1995-04       Impact factor: 26.132

3.  Structure-activity correlation study of HIV-1 inhibitors: electronic and molecular parameters.

Authors:  S Hannongbua; L Lawtrakul; J Limtrakul
Journal:  J Comput Aided Mol Des       Date:  1996-04       Impact factor: 3.686

4.  Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication.

Authors:  C A Deminie; C M Bechtold; D Stock; M Alam; F Djang; A H Balch; T C Chou; M Prichard; R J Colonno; P F Lin
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

5.  Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.

Authors:  S H Reich; M Melnick; J F Davies; K Appelt; K K Lewis; M A Fuhry; M Pino; A J Trippe; D Nguyen; H Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

6.  Determination of protein binding by in vitro charcoal adsorption.

Authors:  J Yuan; D C Yang; J Birkmeier; J Stolzenbach
Journal:  J Pharmacokinet Biopharm       Date:  1995-02

7.  A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A.

Authors:  M L Smidt; K E Potts; S P Tucker; L Blystone; T R Stiebel; W C Stallings; J J McDonald; D Pillay; D D Richman; M L Bryant
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

8.  Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors.

Authors:  R E Rose; Y F Gong; J A Greytok; C M Bechtold; B J Terry; B S Robinson; M Alam; R J Colonno; P F Lin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

9.  Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease.

Authors:  C M Bechtold; A K Patick; M Alam; J Greytok; J A Tino; P Chen; E Gordon; S Ahmad; J C Barrish; R Zahler
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

10.  Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  J Med Chem       Date:  2019-12-02       Impact factor: 7.446
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