Literature DB >> 8423459

The use of monoclonal antibodies in diagnostic tests for Becker and Duchenne muscular dystrophy.

R Gold1, W Kress, H Reichmann, C R Müller.   

Abstract

Monoclonal antibodies recognizing different epitopes of dystrophin have now been widely applied in diagnostic tests for Duchenne and Becker muscular dystrophy (BMD). The preservation of the C-terminus in BMD patients necessitates the routine use of one antibody raised against this region. Additional antibodies against deletion-prone regions of dystrophin further increase the diagnostic power of the tests. We describe two cases which illustrate that the combined use of different antibodies is necessary to avoid misdiagnoses of BMD at the protein level.

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Year:  1993        PMID： 8423459     DOI： 10.1007/bf00838441

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  18 in total

1.  Duchenne muscular dystrophy: evidence for somatic reversion of the mutation in man.

Authors:  R Gold; B Meurers; H Reichmann; W Kress; C R Müller
Journal:  J Neurol       Date:  1990-12       Impact factor: 4.849

2.  Point mutation in the human dystrophin gene: identification through western blot analysis.

Authors:  D E Bulman; S B Gangopadhyay; K G Bebchuck; R G Worton; P N Ray
Journal:  Genomics       Date:  1991-06       Impact factor: 5.736

3.  Protein sequence of DMD gene is related to actin-binding domain of alpha-actinin.

Authors:  R G Hammonds
Journal:  Cell       Date:  1987-10-09       Impact factor: 41.582

4.  Heterogeneity of dystrophin expression in patients with Duchenne and Becker muscular dystrophy.

Authors:  L V Nicholson; M A Johnson; D Gardner-Medwin; S Bhattacharya; J B Harris
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

5.  Immunohistochemical studies show truncated dystrophins in the myotubes of three fetuses at risk for Duchenne muscular dystrophy.

Authors:  I B Ginjaar; E Bakker; M M van Paassen; J T den Dunnen; A Wessels; E E Zubrzycka-Gaarn; A F Moorman; G J van Ommen
Journal:  J Med Genet       Date:  1991-08       Impact factor: 6.318

6.  Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs.

Authors:  G Acsadi; G Dickson; D R Love; A Jani; F S Walsh; A Gurusinghe; J A Wolff; K E Davies
Journal:  Nature       Date:  1991-08-29       Impact factor: 49.962

7.  Dystrophin as a diagnostic marker in Duchenne and Becker muscular dystrophy. Correlation of immunofluorescence and western blot.

Authors:  T Voit; P Stuettgen; M Cremer; H H Goebel
Journal:  Neuropediatrics       Date:  1991-08       Impact factor: 1.947

8.  The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein.

Authors:  M Koenig; A P Monaco; L M Kunkel
Journal:  Cell       Date:  1988-04-22       Impact factor: 41.582

9.  Exploring the molecular basis for variability among patients with Becker muscular dystrophy: dystrophin gene and protein studies.

Authors:  A H Beggs; E P Hoffman; J R Snyder; K Arahata; L Specht; F Shapiro; C Angelini; H Sugita; L M Kunkel
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025

10.  Is the carboxyl-terminus of dystrophin required for membrane association? A novel, severe case of Duchenne muscular dystrophy.

Authors:  E P Hoffman; C A Garcia; J S Chamberlain; C Angelini; J R Lupski; R Fenwick
Journal:  Ann Neurol       Date:  1991-10       Impact factor: 10.422
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  1 in total

1.  Abnormal dystrophin expression in patients with limb girdle syndromes.

Authors:  S Beyenburg; S Zierz; K Arahata; R R Mundegar; W Friedl; F Jerusalem
Journal:  J Neurol       Date:  1994-02       Impact factor: 4.849
  1 in total

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