Literature DB >> 8423063

Altered antigen expression of microglia in the aged rodent CNS.

V H Perry1, M K Matyszak, S Fearn.   

Abstract

Microglia, the resident macrophages of the central nervous system, are characterised by a highly specialized morphology and unusual antigenic phenotype. Microglia appear to be downregulated by their microenvironment when compared to other tissue macrophages. We have studied the microglia in brains of healthy, aged rats with a panel of monoclonal antibodies. We have found that microglia in the brains of these aged rats express antigens that are downregulated or absent from microglia of juvenile rats. The stimuli which give rise to this upregulated phenotype are not known. Age related changes in the phenotype of microglia should be taken into account when considering the possible role of microglia in neuropathological conditions.

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Year:  1993        PMID： 8423063     DOI： 10.1002/glia.440070111

Source DB:  PubMed          Journal:  Glia        ISSN： 0894-1491            Impact factor:   7.452


  107 in total

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Review 7.  Review: microglia of the aged brain: primed to be activated and resistant to regulation.

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Journal:  Neuropathol Appl Neurobiol       Date:  2013-02       Impact factor: 8.090

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Authors:  Lauren M Willis; Linnea Freeman; Paula C Bickford; E Matthew Quintero; Claudia D Umphlet; Alfred B Moore; Laura Goetzl; Ann-Charlotte Granholm
Journal:  Glia       Date:  2010-04-15       Impact factor: 7.452

9.  Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines.

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10.  Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.

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Journal:  Brain Behav Immun       Date:  2008-07-11       Impact factor: 7.217
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