Literature DB >> 8422238

Beta 3 integrin derived peptide 217-230 inhibits fibrinogen binding and platelet aggregation: significance of RGD sequences and fibrinogen A alpha-chain.

E C Lasz1, M A McLane, M Trybulec, M A Kowalska, S Khan, A Z Budzynski, S Niewiarowski.   

Abstract

beta 3 Integrin derived peptides 217-230 (DAPEGGFDAIMQAT) and 217-231 (Y) (DAPEGGFDAIMQATVY) at 100 microM inhibited 125I-fibrinogen binding to ADP-stimulated platelets and platelet aggregation. Peptide 217-231 (Y) (100 microM) significantly inhibited the binding of 125I-albolabrin (a disintegrin with a single RGD sequence) to ADP- and thrombin-activated platelets while it had only a slight effect on albolabrin binding to resting platelets. The 125I-beta 3 217-231 (Y) cross-linked selectively to the fibrinogen A alpha-chain. The interaction of the RGD sequence in the A alpha-chain of fibrinogen with beta 3 217-231 sequence appears to play a significant role in the events leading to platelet aggregation.

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Year:  1993        PMID： 8422238     DOI： 10.1006/bbrc.1993.1019

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

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Authors:  J Gabbeta; X Yang; M A Kowalska; L Sun; N Dhanasekaran; A K Rao
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

2.  The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanking the sequence RGD.

Authors:  S Rahman; X Lu; V V Kakkar; K S Authi
Journal:  Biochem J       Date:  1995-11-15       Impact factor: 3.857

3.  Interaction of disintegrins with the alpha IIb beta 3 receptor on resting and activated human platelets.

Authors:  M A McLane; M A Kowalska; L Silver; S J Shattil; S Niewiarowski
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

4.  Uniform and accelerated degradation of pure iron patterned by Pt disc arrays.

Authors:  Tao Huang; Yufeng Zheng
Journal:  Sci Rep       Date:  2016-04-01       Impact factor: 4.379
  4 in total

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