BACKGROUND AND PURPOSE: The precise mechanism of neurological symptoms with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) is still controversial. We investigated the correlation between strokelike episodes and cerebral blood flow in two patients with MELAS and discuss the pathogenesis of strokelike episodes with MELAS. SUMMARY OF REPORT: Cerebral dynamic computed tomography and cerebral angiography were used to measure cerebral circulation in the first case, that of a 20-year-old woman with MELAS. The second subject was a 13-year-old female who was studied with xenon-enhanced computed tomography. The cerebral blood flow studies were performed 3-72 hours after the onset of strokelike episodes. Serial cerebral angiography, dynamic computed tomography, and xenon-enhanced computed tomography showed vasodilation localized in the affected cerebral cortexes during strokelike episodes, without any reduction in regional cerebral blood flow. CONCLUSIONS: Our study suggests that the strokelike episodes associated with MELAS are different in origin from ischemic stroke.
BACKGROUND AND PURPOSE: The precise mechanism of neurological symptoms with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) is still controversial. We investigated the correlation between strokelike episodes and cerebral blood flow in two patients with MELAS and discuss the pathogenesis of strokelike episodes with MELAS. SUMMARY OF REPORT: Cerebral dynamic computed tomography and cerebral angiography were used to measure cerebral circulation in the first case, that of a 20-year-old woman with MELAS. The second subject was a 13-year-old female who was studied with xenon-enhanced computed tomography. The cerebral blood flow studies were performed 3-72 hours after the onset of strokelike episodes. Serial cerebral angiography, dynamic computed tomography, and xenon-enhanced computed tomography showed vasodilation localized in the affected cerebral cortexes during strokelike episodes, without any reduction in regional cerebral blood flow. CONCLUSIONS: Our study suggests that the strokelike episodes associated with MELAS are different in origin from ischemic stroke.
Authors: Ji Hye Kim; Myung Kwan Lim; Tae Yeon Jeon; Joung Ho Rha; Jung Ho Rha; Hong Eo; So-Young Yoo; Chang Hae Shu Journal: Korean J Radiol Date: 2011-01-03 Impact factor: 3.500
Authors: C M Sue; D S Crimmins; Y S Soo; R Pamphlett; C M Presgrave; N Kotsimbos; M J Jean-Francois; E Byrne; J G Morris Journal: J Neurol Neurosurg Psychiatry Date: 1998-08 Impact factor: 10.154
Authors: Yi Shiau Ng; Laurence A Bindoff; Gráinne S Gorman; Rita Horvath; Thomas Klopstock; Michelangelo Mancuso; Mika H Martikainen; Robert Mcfarland; Victoria Nesbitt; Robert D S Pitceathly; Andrew M Schaefer; Doug M Turnbull Journal: Wellcome Open Res Date: 2019-12-13