D A Imoedemhe1, A B Sigue. 1. Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
Abstract
OBJECTIVE: To assess the value of subzonal sperm injection in previous failed spontaneous in vitro fertilization (IVF). DESIGN: Prospective study on patients with at least one cycle of previous failed spontaneous IVF. SETTING: Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah, Saudi Arabia. PATIENTS: Thirty-nine patients with prolonged infertility with at least one previous cycle of failure of spontaneous fertilization of any oocyte. RESULTS: Seventy-eight of 276 oocytes successfully injected with three to four sperms were fertilized. Fertilized rate was 28.2%. Polyspermy was observed in 6 (8%) of the fertilized oocytes. Sixty-six (92%) of the 72 with monospermic fertilization cleaved normally and were replaced in the uterine cavity. Pregnancy occurred in 6 (23%) of the women who had embryos replaced. CONCLUSIONS: Multiple sperm injection into the oocyte subzonal space should be considered for the treatment of patients with previous failed spontaneous IVF.
OBJECTIVE: To assess the value of subzonal sperm injection in previous failed spontaneous in vitro fertilization (IVF). DESIGN: Prospective study on patients with at least one cycle of previous failed spontaneous IVF. SETTING:Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah, Saudi Arabia. PATIENTS: Thirty-nine patients with prolonged infertility with at least one previous cycle of failure of spontaneous fertilization of any oocyte. RESULTS: Seventy-eight of 276 oocytes successfully injected with three to four sperms were fertilized. Fertilized rate was 28.2%. Polyspermy was observed in 6 (8%) of the fertilized oocytes. Sixty-six (92%) of the 72 with monospermic fertilization cleaved normally and were replaced in the uterine cavity. Pregnancy occurred in 6 (23%) of the women who had embryos replaced. CONCLUSIONS: Multiple sperm injection into the oocyte subzonal space should be considered for the treatment of patients with previous failed spontaneous IVF.