Literature DB >> 8418062

Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection.

L Zenner1, F Darcy, M F Cesbron-Delauw, A Capron.   

Abstract

The incidence of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from chronically infected mothers are protected from congenital toxoplasmosis, rat infection could thus constitute a relevant model for immunological studies and vaccine design.

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Year:  1993        PMID： 8418062      PMCID： PMC302731          DOI： 10.1128/iai.61.1.360-363.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Studies on chronic toxoplasmosis; the relation of infective dose to residual infection and to the possibility of congenital transmission.

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Journal:  Am J Ophthalmol       Date:  1958-11       Impact factor: 5.258

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Journal:  Nature       Date:  1959-05-09       Impact factor: 49.962

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Journal:  Bull N Y Acad Med       Date:  1974-02

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Authors:  F Darcy; D Deslee; F Santoro; H Charif; C Auriault; A Decoster; V Duquesne; A Capron
Journal:  Parasite Immunol       Date:  1988-09       Impact factor: 2.280

5.  A study of cataract in murine congenital toxoplasmosis.

Authors:  W M Hutchison; J Hay; W R Lee; J C Siim
Journal:  Ann Trop Med Parasitol       Date:  1982-02

6.  Studies on a murine model of congenital toxoplasmosis: vertical disease transmission only occurs in BALB/c mice infected for the first time during pregnancy.

Authors:  C W Roberts; J Alexander
Journal:  Parasitology       Date:  1992-02       Impact factor: 3.234

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Authors:  F Santoro; C Auriault; P Leite; F Darcy; A Capron
Journal:  C R Acad Sci III       Date:  1987

8.  Host-parasite relationship in the brains of mice with congenital toxoplasmosis.

Authors:  T A Sims; J Hay; I C Talbot
Journal:  J Pathol       Date:  1988-11       Impact factor: 7.996

9.  Isotypic profiles of antibody responses to Toxoplasma gondii infection in rats and mice: kinetic study and characterization of target antigens of immunoglobulin A antibodies.

Authors:  I Godard; F Darcy; D Deslee; J P Dessaint; A Capron
Journal:  Infect Immun       Date:  1990-08       Impact factor: 3.441

10.  Experimental congenital toxoplasmosis. I. The vagina as a portal of entry of toxoplasma in the mouse.

Authors:  D COWEN; A WOLF
Journal:  J Exp Med       Date:  1950-11-01       Impact factor: 14.307
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  9 in total

1.  Protective immunity against congenital toxoplasmosis with recombinant SAG1 protein in a guinea pig model.

Authors:  M Haumont; L Delhaye; L Garcia; M Jurado; P Mazzu; V Daminet; V Verlant; A Bollen; R Biemans; A Jacquet
Journal:  Infect Immun       Date:  2000-09       Impact factor: 3.441

2.  Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii.

Authors:  Erin M Garrison; Gustavo Arrizabalaga
Journal:  Mol Microbiol       Date:  2009-03-04       Impact factor: 3.501

3.  Different subsets of T cells in conjunction with natural killer cells, macrophages, and activated microglia participate in the intracerebral immune response to Toxoplasma gondii in athymic nude and immunocompetent rats.

Authors:  D Schlüter; A Hein; R Dörries; M Deckert-Schlüter
Journal:  Am J Pathol       Date:  1995-04       Impact factor: 4.307

Review 4.  Maternal vaccination: moving the science forward.

Authors:  Azure N Faucette; Benjamin L Unger; Bernard Gonik; Kang Chen
Journal:  Hum Reprod Update       Date:  2014-07-11       Impact factor: 15.610

5.  Toxoplasma gondii: induction of egress by the potassium ionophore nigericin.

Authors:  Ingrid A Fruth; Gustavo Arrizabalaga
Journal:  Int J Parasitol       Date:  2007-06-09       Impact factor: 3.981

6.  A Toxoplasma gondii mutant defective in responding to calcium fluxes shows reduced in vivo pathogenicity.

Authors:  Mark D Lavine; Laura J Knoll; Peggy J Rooney; Gustavo Arrizabalaga
Journal:  Mol Biochem Parasitol       Date:  2007-06-19       Impact factor: 1.759

7.  Tumor necrosis factor alpha, interleukin 1 alpha, and interleukin 6 mRNA expressed by human astrocytoma cells after infection by three different strains of Toxoplasma gondii.

Authors:  H Pelloux; J Ricard; V Bracchi; Y Markowicz; J M Verna; P Ambroise-Thomas
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

8.  Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation.

Authors:  Gustavo Arrizabalaga; Felix Ruiz; Silvia Moreno; John C Boothroyd
Journal:  J Cell Biol       Date:  2004-06-01       Impact factor: 10.539

9.  Immunopathogenesis of toxoplasmosis in pregnancy.

Authors:  J Dupouy-Camet
Journal:  Infect Dis Obstet Gynecol       Date:  1997
  9 in total

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