Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.

Literature DB >> 8418058

Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.

I M Orme¹, S K Furney, P S Skinner, A D Roberts, P J Brennan, D G Russell, H Shiratsuchi, J J Ellner, W Y Weiser.

Abstract

Infections caused by Mycobacterium avium, the most common form of diseminated bacterial disease in AIDS patients, are difficult to treat because of their resistance to many antimycobacterial drugs. The results of the present study show that recombinant migration inhibitory factor, a 12-kDa molecule recently isolated by COS-1 cell expression screening of cDNA from a human T-cell hybridoma, has potent inhibitory activity on the growth of a panel of clinical isolates of M. avium within both bone-marrow-derived murine macrophages and cultured human blood monocytes. These cells cultured in recombinant migration inhibitory factor exhibit various signs of activation, including cell division, morphological changes such as evidence of substantial phagolysosomal fusion, and enhanced secretion of tumor necrosis factor.

Entities: Disease Species

Mesh：

Substances：

Year: 1993 PMID： 8418058 PMCID： PMC302726 DOI： 10.1128/iai.61.1.338-342.1993

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

33 in total

1. Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy.

Authors: C F Nathan; G Kaplan; W R Levis; A Nusrat; M D Witmer; S A Sherwin; C K Job; C R Horowitz; R M Steinman; Z A Cohn
Journal: N Engl J Med Date: 1986-07-03 Impact factor: 91.245

2. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

Authors: J R David
Journal: Proc Natl Acad Sci U S A Date: 1966-07 Impact factor: 11.205

3. A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells.

Authors: A Nakagawara; C F Nathan
Journal: J Immunol Methods Date: 1983-01-28 Impact factor: 2.303

4. Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients.

Authors: G Kaplan; A Nusrat; E N Sarno; C K Job; J McElrath; J A Porto; C F Nathan; Z A Cohn
Journal: Am J Pathol Date: 1987-08 Impact factor: 4.307

5. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

Authors: B R Bloom; B Bennett
Journal: Science Date: 1966-07-01 Impact factor: 47.728

6. Tumor necrosis factor (TNF).

Authors: L J Old
Journal: Science Date: 1985-11-08 Impact factor: 47.728

7. Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex.

Authors: L E Bermudez; L S Young
Journal: J Immunol Date: 1988-05-01 Impact factor: 5.422

8. Generation of human hybridomas producing migration inhibitory factor (MIF) and of murine hybridomas secreting monoclonal antibodies to human MIF.

Authors: W Y Weiser; H G Remold; J R David
Journal: Cell Immunol Date: 1985-01 Impact factor: 4.868

4. Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

Authors: S Sturgill-Koszycki; U E Schaible; D G Russell
Journal: EMBO J Date: 1996-12-16 Impact factor: 11.598

5. MIF protein are theta-class glutathione S-transferase homologs.

Authors: F A Blocki; L B Ellis; L P Wackett
Journal: Protein Sci Date: 1993-12 Impact factor: 6.725

6. Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages.

Authors: R Appelberg; I M Orme
Journal: Immunology Date: 1993-11 Impact factor: 7.397

6 in total