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Literature DB >> 8417499

Function and regulation of the human multidrug resistance gene.

Abstract

The discovery of an energy-dependent pump system for natural product anticancer drugs has important implications for the biology of related energy-dependent transport systems as well as for the treatment of human cancer. To fully realize the therapeutic potential associated with manipulation of the multidrug transporter, it will be necessary to understand the mechanisms of action of the transporter and its mode of regulation. This review has summarized recent developments in these areas which suggest that both the activity of the pump and its genetic regulation are potential targets for new anticancer therapies.

Entities: Disease Species

Mesh：

Substances：
Protein Kinases

Year: 1993 PMID： 8417499 DOI： 10.1016/s0065-230x(08)60825-8

Source DB: PubMed Journal: Adv Cancer Res ISSN： 0065-230X Impact factor: 6.242

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Cited

26 in total

1. Characterization of the rat mdr2 promoter and its regulation by the transcription factor Sp1.

Authors: P C Brown; J A Silverman
Journal: Nucleic Acids Res Date: 1996-08-15 Impact factor: 16.971

2. Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors.

Authors: A Krautheim; P Brechlin; K Becker; M Winkler; H J Steinfelder
Journal: Br J Pharmacol Date: 2000-02 Impact factor: 8.739

3. New chemosensitivity test using a thermo-reversible gelation polymer for recurrent gynecologic cancer patients and a preliminary study of mechanisms of anticancer drug resistance.

Authors: Tatsuru Ohara; Kazushige Kiguchi; Satoshi Tsukikawa; Sojiro Sato; Yoichi Kobayashi; Bunpei Ishizuka; Sunao Kubota
Journal: Hum Cell Date: 2005-09 Impact factor: 4.174

8. Influence of cytokines on mdr1 expression in human colon carcinoma cell lines: increased cytotoxicity of MDR relevant drugs.

Authors: W Walther; U Stein
Journal: J Cancer Res Clin Oncol Date: 1994 Impact factor: 4.553

Review 9. Modulation of tumor cell gene expression and phenotype by the organ-specific metastatic environment.

Authors: R Radinsky
Journal: Cancer Metastasis Rev Date: 1995-12 Impact factor: 9.264

10. Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1.

Authors: Ying Huang; Paul E Blower; Ruqing Liu; Zunyan Dai; Anh-Nhan Pham; Hojin Moon; Jialong Fang; Wolfgang Sadée
Journal: Pharm Res Date: 2007-04-25 Impact factor: 4.200

Function and regulation of the human multidrug resistance gene.

1. Characterization of the rat mdr2 promoter and its regulation by the transcription factor Sp1.

2. Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors.

3. New chemosensitivity test using a thermo-reversible gelation polymer for recurrent gynecologic cancer patients and a preliminary study of mechanisms of anticancer drug resistance.

Review 4. Characterization and functional reconstitution of the multidrug transporter.

Review 5. Molecular analysis of the multidrug transporter.

Review 6. Topoisomerase I in multiple drug resistance.

7. Ribozyme-mediated reversal of the multidrug-resistant phenotype.

8. Influence of cytokines on mdr1 expression in human colon carcinoma cell lines: increased cytotoxicity of MDR relevant drugs.

Review 9. Modulation of tumor cell gene expression and phenotype by the organ-specific metastatic environment.

10. Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1.