Literature DB >> 8416818

Disulfide bridges in human complement component C3b.

K Dolmer1, L Sottrup-Jensen.   

Abstract

The disulfide bridges of human complement component C3b, derived from C3 by removal of the 77-residue C3a, have been determined. The 10 bridges are Cys537-Cys794, Cys605-Cys640, Cys851-Cys1491, Cys1079-Cys1136, Cys1336-Cys1467, Cys1367-Cys1436, Cys1484-Cys1489, Cys1496-Cys1568, Cys1515-Cys1639, and Cys1615-Cys1624. Including the 3 bridges in C3a (Cys670-Cys698, Cys672-Cys705, and Cys685-Cys706) previously determined by high-resolution X-ray crystallography [Hoppe-Seyler's Z. Physiol. Chem. 361 (1980) 1389-1399] all disulfide bridges of C3 are localized. C3 and the strongly related C4 and C5 are members of the alpha 2-macroglobulin superfamily. The predicted bridge patterns of C4 and C5 are discussed and compared with that of alpha 2-macroglobulin.

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Year:  1993        PMID： 8416818     DOI： 10.1016/0014-5793(93)81139-q

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases.

Authors:  L Bányai; L Patthy
Journal:  Protein Sci       Date:  1999-08       Impact factor: 6.725

2.  Molecular cloning and derived primary structure of cobra venom factor.

Authors:  D C Fritzinger; R Bredehorst; C W Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

3.  Flavoxobin, a serine protease from Trimeresurus flavoviridis (habu snake) venom, independently cleaves Arg726-Ser727 of human C3 and acts as a novel, heterologous C3 convertase.

Authors:  Chieko Yamamoto; Daisuke Tsuru; Naoko Oda-Ueda; Motonori Ohno; Shosaku Hattori; Sung-Teh Kim
Journal:  Immunology       Date:  2002-09       Impact factor: 7.397

4.  Identification and molecular characterization of a complement C3 molecule in a lophotrochozoan, the Hawaiian bobtail squid Euprymna scolopes.

Authors:  Maria G Castillo; Michael S Goodson; Margaret McFall-Ngai
Journal:  Dev Comp Immunol       Date:  2009       Impact factor: 3.636

5.  A novel mutation in the complement component 3 gene in a patient with selective IgA deficiency.

Authors:  Elisangela Santos-Valente; Ismail Reisli; Hasibe Artaç; Raphael Ott; Özden Sanal; Kaan Boztug
Journal:  J Clin Immunol       Date:  2012-09-21       Impact factor: 8.317
  5 in total

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