Literature DB >> 8415683

Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure.

P Schimmell1.   

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Year:  1993        PMID: 8415683      PMCID: PMC47541          DOI: 10.1073/pnas.90.20.9235

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


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  11 in total

1.  Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.

Authors:  W R Montfort; K M Perry; E B Fauman; J S Finer-Moore; G F Maley; L Hardy; F Maley; R M Stroud
Journal:  Biochemistry       Date:  1990-07-31       Impact factor: 3.162

2.  Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate.

Authors:  D A Matthews; K Appelt; S J Oatley; N H Xuong
Journal:  J Mol Biol       Date:  1990-08-20       Impact factor: 5.469

3.  Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.

Authors:  K M Perry; E B Fauman; J S Finer-Moore; W R Montfort; G F Maley; F Maley; R M Stroud
Journal:  Proteins       Date:  1990

4.  Atomic structure of thymidylate synthase: target for rational drug design.

Authors:  L W Hardy; J S Finer-Moore; W R Montfort; M O Jones; D V Santi; R M Stroud
Journal:  Science       Date:  1987-01-23       Impact factor: 47.728

5.  Saturation site-directed mutagenesis of thymidylate synthase.

Authors:  S Climie; L Ruiz-Perez; D Gonzalez-Pacanowska; P Prapunwattana; S W Cho; R Stroud; D V Santi
Journal:  J Biol Chem       Date:  1990-11-05       Impact factor: 5.157

6.  Structure-based discovery of inhibitors of thymidylate synthase.

Authors:  B K Shoichet; R M Stroud; D V Santi; I D Kuntz; K M Perry
Journal:  Science       Date:  1993-03-05       Impact factor: 47.728

7.  Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase.

Authors:  L Liu; D V Santi
Journal:  Biochemistry       Date:  1993-09-14       Impact factor: 3.162

8.  Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity.

Authors:  L W Hardy; E Nalivaika
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

9.  Probing the structure and mechanism of Ras protein with an expanded genetic code.

Authors:  H H Chung; D R Benson; P G Schultz
Journal:  Science       Date:  1993-02-05       Impact factor: 47.728

10.  Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis.

Authors:  L Liu; D V Santi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

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  1 in total

1.  Mutational analysis of the active site of indoleglycerol phosphate synthase from Escherichia coli.

Authors:  B Darimont; C Stehlin; H Szadkowski; K Kirschner
Journal:  Protein Sci       Date:  1998-05       Impact factor: 6.725

  1 in total

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