| Literature DB >> 841483 |
R L Jordan, J G Wilson, H J Schumacher.
Abstract
The prenatal effects of methotrexate (MTX) in rats and rabbits were assessed. It was found highly embryotoxic in postimplantation rat embryos; 0.3 mg/kg ip or less caused nearly total embryolethality with slight teratogenicity. Rabbit embryos were far more resistant to small doses of MTX than rats, but 19.2 mg/kg iv, when given during days 10 to 15 of gestation, produced little death and a constant spectrum of malformation in a high percentage of offspring. Cleft palate, skull defects, and severe fore- and hindlimb dysplasias, occurred with a high degree of regularity and were strongly dose and developmental-stage specific.Entities:
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Year: 1977 PMID： 841483 DOI： 10.1002/tera.1420150110
Source DB: PubMed Journal: Teratology ISSN： 0040-3709