| Literature DB >> 8414189 |
P Mailleux1, J J Vanderhaeghen.
Abstract
The influence of adrenalectomy on cannabinoid receptor gene expression in the adult rat dorsal striatum was investigated by in situ hybridization with specific oligonucleotide probes. The caudate-putamen of adrenalectomized rats contains approximately 50% significantly higher mRNA levels than the controls. This increase could be counteracted by dexamethasone treatment. Together, these results suggest glucocorticoid down-regulation of cannabinoid receptor gene expression in the striatum.Entities:
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Year: 1993 PMID: 8414189 DOI: 10.1016/0304-3940(93)90437-p
Source DB: PubMed Journal: Neurosci Lett ISSN: 0304-3940 Impact factor: 3.046