Literature DB >> 8412562

Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain.

H Chou1, N Ogawa, M Asanuma, H Hirata, Y Kondo, A Mori.   

Abstract

The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.

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Year:  1993        PMID： 8412562     DOI： 10.1016/0169-328x(93)90028-n

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  2 in total

1.  Mechanisms involved in the regulation of mRNA for M2 muscarinic acetylcholine receptors and endothelial and neuronal NO synthases in rat atria.

Authors:  S Ganzinelli; L Joensen; E Borda; G Bernabeo; L Sterin-Borda
Journal:  Br J Pharmacol       Date:  2007-03-26       Impact factor: 8.739

2.  Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.

Authors:  Seok-Joo Park; Eun-Joo Shin; Sun Seek Min; Jihua An; Zhengyi Li; Yoon Hee Chung; Ji Hoon Jeong; Jae-Hyung Bach; Seung-Yeol Nah; Won-Ki Kim; Choon-Gon Jang; Yong-Sun Kim; Yo-Ichi Nabeshima; Toshitaka Nabeshima; Hyoung-Chun Kim
Journal:  Neuropsychopharmacology       Date:  2013-02-06       Impact factor: 7.853
  2 in total

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