Literature DB >> 8412473

Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice.

H Nagai1, S Yamaguchi, N Inagaki, N Tsuruoka, Y Hitoshi, K Takatsu.   

Abstract

The effect of pretreatment with rat anti-murine interleukin-5 (IL-5) antibody on antigen-induced bronchial eosinophilia and bronchial reactivity to acetylcholine in mice were studied. Three inhalations of an antigen by actively sensitized animals resulted in an increase in airway reactivity to acetylcholine. Twenty-four hours after the final inhalation, the number of leukocytes (mononuclear cells and eosinophils) and the amount of IL-5 in BALF increased significantly. Anti-IL-5 monoclonal antibody inhibited the antigen-induced increase of eosinophils with little effect on bronchial hyperreactivity.

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Year:  1993        PMID： 8412473     DOI： 10.1016/0024-3205(93)90545-e

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  8 in total

1.  Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.

Authors:  Yuko Kawakami; Naoki Inagaki; Shahram Salek-Ardakani; Jiro Kitaura; Hiroyuki Tanaka; Koichi Nagao; Yu Kawakami; Wenbin Xiao; Hiroichi Nagai; Michael Croft; Toshiaki Kawakami
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-21       Impact factor: 11.205

2.  Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma.

Authors:  R R Dickason; J D English; D P Huston
Journal:  J Mol Med (Berl)       Date:  1996-09       Impact factor: 4.599

3.  An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.

Authors:  J Temelkovski; S P Hogan; D P Shepherd; P S Foster; R K Kumar
Journal:  Thorax       Date:  1998-10       Impact factor: 9.139

4.  Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation.

Authors:  R Sehmi; L J Wood; R Watson; R Foley; Q Hamid; P M O'Byrne; J A Denburg
Journal:  J Clin Invest       Date:  1997-11-15       Impact factor: 14.808

5.  Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model.

Authors:  Keiki Ogino; Masayuki Kubo; Hidekazu Takahashi; Ran Zhang; Yu Zou; Yoshihisa Fujikura
Journal:  Inflammation       Date:  2013-02       Impact factor: 4.092

6.  Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma.

Authors:  J J Lee; M P McGarry; S C Farmer; K L Denzler; K A Larson; P E Carrigan; I E Brenneise; M A Horton; A Haczku; E W Gelfand; G D Leikauf; N A Lee
Journal:  J Exp Med       Date:  1997-06-16       Impact factor: 14.307

7.  Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma.

Authors:  Joerg Mattes; Ming Yang; Surendran Mahalingam; Joachim Kuehr; Dianne C Webb; Ljubov Simson; Simon P Hogan; Aulikki Koskinen; Andrew N J McKenzie; Lindsay A Dent; Marc E Rothenberg; Klaus I Matthaei; Ian G Young; Paul S Foster
Journal:  J Exp Med       Date:  2002-06-03       Impact factor: 14.307

8.  Allergic airway inflammation by nasal inoculation of particulate matter (PM2.5) in NC/Nga mice.

Authors:  Keiki Ogino; Ran Zhang; Hidekazu Takahashi; Kei Takemoto; Masayuki Kubo; Ikuo Murakami; Da-Hong Wang; Yoshihisa Fujikura
Journal:  PLoS One       Date:  2014-03-26       Impact factor: 3.240
  8 in total

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