| Literature DB >> 841098 |
J P Famaey, J Fontaine, J Reuse.
Abstract
In addition to their well-known effect at low concentrations on prostaglandin synthesis or their release and production, 11 non-steroidal antiinflammatory drugs and 4 antiinflammatory steroids exhibit at high concentrations a direct antagonism on certain prostaglandin actions. This is demonstrated on PGE1- and PGF2alpha-induced contractions of guinea-pig isolated ileum when compared to acetylcholine-induced contractions. This inhibitory effect is totally reversible after washing out the drugs from the organ bath.Entities:
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Year: 1977 PMID： 841098 DOI： 10.1016/0090-6980(77)90047-8
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980