| Literature DB >> 8410492 |
R M Porter1, T C Holme, E L Newman, D Hopwood, J M Wilkinson, A Cuschieri.
Abstract
Monoclonal antibodies raised to a number of microfilament-associated proteins were shown to recognize the appropriate proteins in extracts from human colon tissue. They were then used in an immunohistochemical study of normal colonic mucosa, adenomas, and adenocarcinomas. A strong reaction was seen in stromal cells within the tumours (both adenomas and adenocarcinomas) when frozen sections were stained with antibodies to filamin and caldesmon. In addition, a similar reaction was seen in the adenocarcinomas when stained with antibodies to talin and gelsolin. We believe that immunohistochemical staining with these antibodies reveals a tumour-induced process in the surrounding cells, possibly related to a host response to tumours.Entities:
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Year: 1993 PMID： 8410492 DOI： 10.1002/path.1711700406
Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996