| Literature DB >> 8409950 |
S Person1, S Laquerre, P Desai, J Hempel.
Abstract
The goal of experiments reported here was to identify the genes that encode capsid proteins VP21 and VP24 of herpes simplex virus type 1 (HSV-1). Capsids were isolated from infected cells and the proteins were separated by SDS-PAGE. N-terminal amino acid sequence analysis of partial CNBr digestion products, and of intact VP21, showed that it is encoded within the UL26 open reading frame (ORF) of HSV-1 beginning with codon 248 and probably extending to the end of the ORF (codon 635). Similar analysis of digestion products confirmed that VP24 is specified by codons 1 to 247 at the 5' end of the UL26 ORF. Each of the seven known capsid proteins has now been assigned to an ORF.Entities:
Mesh:
Year: 1993 PMID: 8409950 DOI: 10.1099/0022-1317-74-10-2269
Source DB: PubMed Journal: J Gen Virol ISSN: 0022-1317 Impact factor: 3.891