| Literature DB >> 8407580 |
K Kuroda1, M Yoshida, Y Uosaki, K Ando, I Kawamoto, E Oishi, H Onuma, K Yamada, Y Matsuda.
Abstract
A novel compound, AS-183, which inhibits acyl-CoA: cholesterol acyltransferase (ACAT), was isolated from the culture broth of a fungus, Scedosporium sp. SPC-15549. AS-183 inhibited ACAT activity in an enzyme assay system using rabbit liver microsomes with an IC50 value of 0.94 microM. AS-183 also inhibited cholesterol ester formation in HepG2, CaCo2, and THP-1 cells with IC50 values of 18.1, 25.5, and 34.5 microM, respectively.Entities:
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Year: 1993 PMID： 8407580 DOI： 10.7164/antibiotics.46.1196
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649