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Literature DB >> 8407544

HTLV-1-associated myelopathy/tropical spastic paraparesis-like rats by intravenous injection of HTLV-1-producing rabbit or human T-cell line into adult WKA rats.

S Kushida¹, M Matsumura, H Tanaka, Y Ami, M Hori, M Kobayashi, K Uchida, K Yagami, T Kameyama, T Yoshizawa.

Abstract

We intravenously injected Ra-1 cells or MT-2 cells into female adult WKA rats. Spastic paraparesis mainly in the hind-limbs was observed in 1 out of 2 Ra-1 cell-injected WKA rats and in 3 out of 8 MT-2 cell-injected WKA rats 20-27 months after injection. The main neuropathological finding was symmetrical white matter degeneration with mononuclear cell infiltration of the spinal cord, similar to that of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, and degeneration of nerve roots and peripheral nerves. Antibodies against HTLV-1 antigens were detected in plasma and cerebrospinal fluid from these HAM/TSP-like rats. HTLV-1 provirus was detected from the peripheral blood mononuclear cells of one of these rats 20 months after injection. Interestingly, spastic paraparesis was not observed in F344 rats.

Entities: CellLine Disease Gene Species

Mesh：

Substances：
HTLV-I Antibodies

Year: 1993 PMID： 8407544 PMCID： PMC5919272 DOI： 10.1111/j.1349-7006.1993.tb02052.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

18 in total

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