Literature DB >> 8407054

Macrophage functions in drugs of abuse-treated mice.

R Pacifici1, S Di Carlo, A Bacosi, P Zuccaro.   

Abstract

The in vivo effect of morphine, methadone and cocaine on murine peritoneal macrophage-mediated cytostasis and macrophage supernatant mediated cytostasis was investigated. In addition, the activity of drugs of abuse was studied on IL-1 alpha and TNF production by activated murine macrophages. A highly depressive effect on macrophage-mediated cytostatic activity and a decrease of IL-1 alpha and TNF levels were found in the supernatants of activated macrophages observed in morphine- and cocaine-treated mice. Conversely, a significant impairment of macrophage functions was not observed in methadone-treated mice. Our results suggest that the inhibition of macrophage defensive functions caused by drugs of abuse may be an important cofactor in the pathogenesis of infectious diseases.

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Year:  1993        PMID： 8407054     DOI： 10.1016/0192-0561(93)90143-m

Source DB:  PubMed          Journal:  Int J Immunopharmacol        ISSN： 0192-0561


  8 in total

Review 1.  Microbial infections, immunomodulation, and drugs of abuse.

Authors:  Herman Friedman; Catherine Newton; Thomas W Klein
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132

2.  Cocaine causes increased type I interferon secretion by both L929 cells and murine macrophages.

Authors:  K Grattendick; D B Jansen; D L Lefkowitz; S S Lefkowitz
Journal:  Clin Diagn Lab Immunol       Date:  2000-03

Review 3.  Effects of opioid tolerance and withdrawal on the immune system.

Authors:  Toby K Eisenstein; Rahil T Rahim; Pu Feng; Nita K Thingalaya; Joseph J Meissler
Journal:  J Neuroimmune Pharmacol       Date:  2006-05-23       Impact factor: 4.147

Review 4.  Effects of opioids on the immune system.

Authors:  S Roy; H H Loh
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

Review 5.  Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.

Authors:  Eric A Woodcock; Ansel T Hillmer; Graeme F Mason; Kelly P Cosgrove
Journal:  Mol Neuropsychiatry       Date:  2019-05-09

Review 6.  Intensive Care Unit-acquired infection as a side effect of sedation.

Authors:  Saad Nseir; Demosthenes Makris; Daniel Mathieu; Alain Durocher; Charles-Hugo Marquette
Journal:  Crit Care       Date:  2010-03-15       Impact factor: 9.097

7.  The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users.

Authors:  Jermaine D Jones; Maria A Sullivan; Jeanne M Manubay; Shanthi Mogali; Verena E Metz; Roberto Ciccocioppo; Sandra D Comer
Journal:  Physiol Behav       Date:  2015-10-09

8.  Repeated cocaine administration upregulates CB2 receptor expression in striatal medium-spiny neurons that express dopamine D1 receptors in mice.

Authors:  Hai-Ying Zhang; Lindsay De Biase; Ramesh Chandra; Hui Shen; Qing-Rong Liu; Eliot Gardner; Mary Kay Lobo; Zheng-Xiong Xi
Journal:  Acta Pharmacol Sin       Date:  2021-07-27       Impact factor: 6.150
  8 in total

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