Literature DB >> 8406910

A descriptive and mechanistic study of the interaction between toluene and xylene in humans.

R Tardif1, S Laparé, K Krishnan, J Brodeur.   

Abstract

This study was undertaken to characterize the mechanism of toxicokinetic interaction between toluene (TOL) and m-xylene (XYL) in the rat using physiologically-based toxicokinetic (PBTK) modeling approach. First, the metabolic rate constants were determined by conducting closed-chamber inhalation exposures with individual solvents (Vmax: TOL = 4.8, XYL = 8.4 mg/hr/kg; Km: TOL = 0.55, XYL = 0.2 mg/l). Then, using the same experimental set-up, rats were exposed to different binary mixtures of TOL and XYL. PBTK analysis of the data showed competitive inhibition as the plausible mechanism of TOL/XYL interaction. This mechanistic modeling study suggests that the interaction between TOL and XYL is likely to be observed when the exposure concentration exceeds 50 ppm of each solvent.

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Year:  1993        PMID： 8406910     DOI： 10.1007/bf00381325

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  10 in total

1.  Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats.

Authors:  R Tardif; G L Plaa; J Brodeur
Journal:  Can J Physiol Pharmacol       Date:  1992-03       Impact factor: 2.273

2.  [Metabolic antagonism among benzene, toluene and m-xylene in vitro (author's transl)].

Authors:  T Nakajima; A Sato
Journal:  Sangyo Igaku       Date:  1979-11

3.  Metabolic interaction and disposition of methyl ethyl ketone and m-xylene in rats at single and repeated inhalation exposures.

Authors:  J Liira; E Elovaara; H Raunio; V Riihimäki; K Engström
Journal:  Xenobiotica       Date:  1991-01       Impact factor: 1.908

4.  A physiologically based simulation approach for determining metabolic constants from gas uptake data.

Authors:  M L Gargas; M E Andersen; H J Clewell
Journal:  Toxicol Appl Pharmacol       Date:  1986-12       Impact factor: 4.219

5.  Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1981-07       Impact factor: 5.153

6.  Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues.

Authors:  M L Gargas; R J Burgess; D E Voisard; G H Cason; M E Andersen
Journal:  Toxicol Appl Pharmacol       Date:  1989-03-15       Impact factor: 4.219

7.  Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

Authors:  M E Andersen; M L Gargas; H J Clewell; K M Severyn
Journal:  Toxicol Appl Pharmacol       Date:  1987-06-30       Impact factor: 4.219

8.  In vivo metabolic interactions of benzene and toluene.

Authors:  K J Purcell; G H Cason; M L Gargas; M E Andersen; C C Travis
Journal:  Toxicol Lett       Date:  1990-07       Impact factor: 4.372

9.  Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver.

Authors:  T Nakajima; R S Wang; E Elovaara; S S Park; H V Gelboin; E Hietanen; H Vainio
Journal:  Biochem Pharmacol       Date:  1991-02-01       Impact factor: 5.858

10.  Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in humans.

Authors:  R Tardif; S Laparé; G L Plaa; J Brodeur
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015
  10 in total
  2 in total

Review 1.  Environmental influences on reproductive health: the importance of chemical exposures.

Authors:  Aolin Wang; Amy Padula; Marina Sirota; Tracey J Woodruff
Journal:  Fertil Steril       Date:  2016-08-09       Impact factor: 7.329

Review 2.  Considering the cumulative risk of mixtures of chemicals - a challenge for policy makers.

Authors:  Denis A Sarigiannis; Ute Hansen
Journal:  Environ Health       Date:  2012-06-28       Impact factor: 5.984
  2 in total

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