Literature DB >> 8406897

Effect of cholera toxin on vaccine-induced immunity and infection in murine schistosomiasis mansoni.

A A Akhiani1, L A Nilsson, O Ouchterlony.   

Abstract

Intradermal vaccination of mice with soluble adult worm antigen (SWAP) in combination with Mycobacterium bovis BCG (Swedish strain) induced significant protection against subsequent infection with Schistosoma mansoni cercariae. When cholera toxin (CT) was used as an adjuvant in combination with SWAP or fraction A, no significant protection was observed. However, intradermal vaccination in combination with CT triggered a strong anti-SWAP antibody response and induced a strong delayed-type hypersensitivity response to schistosome antigens (SWAP or fraction A), one significantly higher than that in the SWAP-BCG group. In addition, vaccinating mice intranasally with SWAP or cercarial antigen together with CT as adjuvant failed to induce any significant protection. Surprisingly, mice given CT alone intranasally revealed a significantly enhanced worm burden. These findings suggest that mucosal application of CT may modulate the host-parasite relationship in favor of parasite survival.

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Year:  1993        PMID： 8406897      PMCID： PMC281257          DOI： 10.1128/iai.61.11.4919-4924.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

1.  Combined oral/nasal immunization protects mice from Sendai virus infection.

Authors:  J G Nedrud; X P Liang; N Hague; M E Lamm
Journal:  J Immunol       Date:  1987-11-15       Impact factor: 5.422

Review 2.  Vaccine strategies against schistosomiasis.

Authors:  A Capron; J P Dessaint; M Capron; R J Pierce
Journal:  Immunobiology       Date:  1992-02       Impact factor: 3.144

Review 3.  Cell-mediated immune response to schistosomiasis.

Authors:  S L James; A Sher
Journal:  Curr Top Microbiol Immunol       Date:  1990       Impact factor: 4.291

4.  Protection against influenza virus infection by a two-dose regimen of nasal vaccination using vaccines combined with cholera toxin B subunit.

Authors:  S Tamura; H Kurata; H Funato; T Nagamine; C Aizawa; T Kurata
Journal:  Vaccine       Date:  1989-08       Impact factor: 3.641

5.  Studies on immunity to Schistosoma mansoni in vivo: whole-body irradiation has no effect on vaccine-induced resistance in mice.

Authors:  D A Vignali; Q D Bickle; M G Taylor
Journal:  Parasitology       Date:  1988-02       Impact factor: 3.234

6.  Attempts to induce resistance in mice to Schistosoma japonicum and Schistosoma mansoni by exposure to crude schistosome antigens plus cloned glutathione-S-transferases.

Authors:  G F Mitchell; K M Davern; S M Wood; M D Wright; V P Argyropoulos; K S McLeod; W U Tiu; E G Garcia
Journal:  Immunol Cell Biol       Date:  1990-12       Impact factor: 5.126

7.  Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and respiratory immunity against Sendai virus.

Authors:  X P Liang; M E Lamm; J G Nedrud
Journal:  J Immunol       Date:  1988-09-01       Impact factor: 5.422

8.  A purified 28,000 dalton protein from Schistosoma mansoni adult worms protects rats and mice against experimental schistosomiasis.

Authors:  J M Balloul; J M Grzych; R J Pierce; A Capron
Journal:  J Immunol       Date:  1987-05-15       Impact factor: 5.422

9.  Comparative antigen analysis of different life stages of Schistosoma mansoni by crossed immunoelectrophoresis.

Authors:  A A Akhiani; L A Nilsson; O Ouchterlony
Journal:  Int Arch Allergy Appl Immunol       Date:  1991

10.  Induction of protective immunity against Schistosoma mansoni by vaccination with schistosome paramyosin (Sm97), a nonsurface parasite antigen.

Authors:  E J Pearce; S L James; S Hieny; D E Lanar; A Sher
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205
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  5 in total

1.  The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.

Authors:  Afton L McGowen; Laura P Hale; Christopher P Shelburne; Soman N Abraham; Herman F Staats
Journal:  Vaccine       Date:  2009-04-14       Impact factor: 3.641

2.  Salmonella enterica serovar enteritidis ghosts carrying the Escherichia coli heat-labile enterotoxin B subunit are capable of inducing enhanced protective immune responses.

Authors:  Chetan V Jawale; John Hwa Lee
Journal:  Clin Vaccine Immunol       Date:  2014-03-26

Review 3.  Cholera toxin: a paradigm of a multifunctional protein.

Authors:  Kaushik Bharati; Nirmal K Ganguly
Journal:  Indian J Med Res       Date:  2011-02       Impact factor: 2.375

4.  An investigation into the role of chronic Schistosoma mansoni infection on Human Papillomavirus (HPV) vaccine induced protective responses.

Authors:  Vicky Gent; Rebecca Waihenya; Lucy Kamau; Ruth Nyakundi; Peris Ambala; Thomas Kariuki; Lucy Ochola
Journal:  PLoS Negl Trop Dis       Date:  2019-08-26

5.  Parenteral adjuvant activities of Escherichia coli heat-labile toxin and its B subunit for immunization of mice against gastric Helicobacter pylori infection.

Authors:  R Weltzin; B Guy; W D Thomas; P J Giannasca; T P Monath
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441
  5 in total

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