Literature DB >> 8406443

A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development.

M Gibbs1, A Collick, R G Kelly, A J Jeffreys.   

Abstract

The highly variable mouse minisatellite Hm-2 is located on chromosome 9 and consists of GGCA tetranucleotide repeats with alleles containing up to 5000 repeat units. This locus is unstable with a germline mutation rate to new length alleles of at least 3.6% per gamete. Hm-2 also shows substantial somatic instability, producing mutational mosaicism detectable in 20% of adult mice. Analysis of allele dosage in mice carrying somatic mutations, plus studies of mosaicism in mouse embryos and extraembryonic tissues, suggests that somatic mutant alleles preferentially arise during preimplantation development and particularly during the first two cell divisions after fertilization.

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Year:  1993        PMID： 8406443     DOI： 10.1006/geno.1993.1292

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  18 in total

1.  Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice.

Authors:  Ruth Barber; Mark A Plumb; Emma Boulton; Isabelle Roux; Yuri E Dubrova
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-07       Impact factor: 11.205

2.  Revealing of somatic mosaicism in adult mice by DNA fingerprinting.

Authors:  A P Ryskov; I A Martirosyan; L I Korochkin
Journal:  Dokl Biochem Biophys       Date:  2004 Sep-Oct       Impact factor: 0.788

3.  Identification of microsatellite mutations in parthenogenetic lizards Darevskia armeniaca.

Authors:  D N Malysheva; O N Tokarskaya; F D Danielyan; I S Darevsky; A P Ryskov
Journal:  Dokl Biochem Biophys       Date:  2005 Jan-Feb       Impact factor: 0.788

4.  Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.

Authors:  Carole Yauk; Aris Polyzos; Andrea Rowan-Carroll; Christopher M Somers; Roger W Godschalk; Frederik J Van Schooten; M Lynn Berndt; Igor P Pogribny; Igor Koturbash; Andrew Williams; George R Douglas; Olga Kovalchuk
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-14       Impact factor: 11.205

5.  The adaptive response and protection against heritable mutations and fetal malformation.

Authors:  D R Boreham; J-A Dolling; C Somers; J Quinn; R E J Mitchel
Journal:  Dose Response       Date:  2006-08-25       Impact factor: 2.658

6.  Microsatellite instability in childhood rhabdomyosarcoma is locus specific and correlates with fractional allelic loss.

Authors:  M Visser; J Bras; C Sijmons; P Devilee; L C Wijnaendts; J C van der Linden; P A Voûte; F Baas
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-20       Impact factor: 11.205

Review 7.  Meiotic recombination hotspots: shaping the genome and insights into hypervariable minisatellite DNA change.

Authors:  W P Wahls
Journal:  Curr Top Dev Biol       Date:  1998       Impact factor: 4.897

8.  Air pollution induces heritable DNA mutations.

Authors:  Christopher M Somers; Carole L Yauk; Paul A White; Craig L J Parfett; James S Quinn
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-09       Impact factor: 11.205

9.  Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation.

Authors:  Y E Dubrova; M Plumb; J Brown; J Fennelly; P Bois; D Goodhead; A J Jeffreys
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

10.  Gonosomal mosaicism in myotonic dystrophy patients: involvement of mitotic events in (CTG)n repeat variation and selection against extreme expansion in sperm.

Authors:  G Jansen; P Willems; M Coerwinkel; W Nillesen; H Smeets; L Vits; C Höweler; H Brunner; B Wieringa
Journal:  Am J Hum Genet       Date:  1994-04       Impact factor: 11.025
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