Literature DB >> 8405464

Enhancement of Ca2+ release channel activity by phosphorylation of the skeletal muscle ryanodine receptor.

A Herrmann-Frank1, M Varsányi.   

Abstract

The Ca2+ release channel of rabbit skeletal muscle sarcoplasmic reticulum (SR) can be phosphorylated by membrane associated protein kinase(s) utilizing endogenously synthesized or exogenously added ATP. The channel protein has been enriched in non-phosphorylated and phosphorylated form from heavy SR following solubilization with CHAPS (3-[(3-cholamidopropyl)dimethylammonio-1-propane-sulfonate) and ultracentrifugation on a linear sucrose/CHAPS gradient. Reconstitution of the isolated channels into planar bilayers shows that phosphorylation enhances the open probability by increasing the sensitivity towards micromolar Ca2+ and ATP. The phosphorylation induced enhancement of the channel activity can be reversed by purified protein phosphatase 2A.

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Year:  1993        PMID： 8405464     DOI： 10.1016/0014-5793(93)80640-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

1.  Calsequestrin: more than 'only' a luminal Ca2+ buffer inside the sarcoplasmic reticulum.

Authors:  C Szegedi; S Sárközi; A Herzog; I Jóna; M Varsányi
Journal:  Biochem J       Date:  1999-01-01       Impact factor: 3.857

2.  The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor.

Authors:  H Kermode; A J Williams; R Sitsapesan
Journal:  Biophys J       Date:  1998-03       Impact factor: 4.033

3.  Regulation of the purified Ca2+ release channel/ryanodine receptor complex of skeletal muscle sarcoplasmic reticulum by luminal calcium.

Authors:  A Herrmann-Frank; F Lehmann-Horn
Journal:  Pflugers Arch       Date:  1996-05       Impact factor: 3.657

4.  Voltage change-induced gating transitions of the rabbit skeletal muscle Ca2+ release channel.

Authors:  A Zahradníková; L G Meszáros
Journal:  J Physiol       Date:  1998-05-15       Impact factor: 5.182

5.  Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle.

Authors:  Dong Wook Shin; Zui Pan; Arun Bandyopadhyay; Manjunatha B Bhat; Do Han Kim; Jianjie Ma
Journal:  Biophys J       Date:  2002-11       Impact factor: 4.033

6.  Effects of cytoplasmic and luminal pH on Ca(2+) release channels from rabbit skeletal muscle.

Authors:  D R Laver; K R Eager; L Taoube; G D Lamb
Journal:  Biophys J       Date:  2000-04       Impact factor: 4.033

7.  Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII.

Authors:  A F Dulhunty; D Laver; S M Curtis; S Pace; C Haarmann; E M Gallant
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

8.  Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from skeletal muscle.

Authors:  J Hain; S Nath; M Mayrleitner; S Fleischer; H Schindler
Journal:  Biophys J       Date:  1994-11       Impact factor: 4.033

9.  Activation and labelling of the purified skeletal muscle ryanodine receptor by an oxidized ATP analogue.

Authors:  M Hohenegger; A Herrmann-Frank; M Richter; F Lehmann-Horn
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

10.  Localization of calmodulin binding sites on the ryanodine receptor from skeletal muscle by electron microscopy.

Authors:  T Wagenknecht; J Berkowitz; R Grassucci; A P Timerman; S Fleischer
Journal:  Biophys J       Date:  1994-12       Impact factor: 4.033
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