Literature DB >> 8405460

Fragmentation of DNA in P388D1 macrophages exposed to oxidised low-density lipoprotein.

V C Reid1, S J Hardwick, M J Mitchinson.   

Abstract

Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.

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Year:  1993        PMID： 8405460     DOI： 10.1016/0014-5793(93)80635-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

Authors:  M R Bennett; G I Evan; S M Schwartz
Journal:  J Clin Invest       Date:  1995-05       Impact factor: 14.808

2.  PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes.

Authors:  Rajiv Lochan Tiwari; Vishal Singh; Ankita Singh; Minakshi Rana; Anupam Verma; Nikhil Kothari; Monica Kohli; Jaishri Bogra; Madhu Dikshit; Manoj Kumar Barthwal
Journal:  J Lipid Res       Date:  2014-05-02       Impact factor: 5.922

3.  Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability.

Authors:  S Björkerud; B Björkerud
Journal:  Am J Pathol       Date:  1996-08       Impact factor: 4.307

4.  Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis.

Authors:  E Gulbins; B Brenner; K Schlottmann; J Welsch; H Heinle; U Koppenhoefer; O Linderkamp; K M Coggeshall; F Lang
Journal:  Immunology       Date:  1996-10       Impact factor: 7.397

5.  Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells.

Authors:  K Aupeix; F Toti; N Satta; P Bischoff; J M Freyssinet
Journal:  Biochem J       Date:  1996-03-15       Impact factor: 3.857
  5 in total

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