| Literature DB >> 8405444 |
R Yorikane1, S Sakai, T Miyauchi, T Sakurai, Y Sugishita, K Goto.
Abstract
Endothelin-1 (ET-1) has been demonstrated to induce hypertrophy in cultured cardiac myocytes. We investigated the production of ET-1 in the heart of aorta-banded rats in vivo. Seven days after the banding of the abdominal aorta, rats developed a significant left ventricular hypertrophy. The tissue content of mature ET-1 and the level of expression of prepro ET-1 mRNA were higher in the left ventricle of aorta-banded rats than in those of sham-operated rats. The expression of prepro ET-1 mRNA in the right ventricle was not different between the two groups. These findings indicate that the production of ET-1 increased in the hypertrophied left ventricle, thereby suggesting the possible involvement of endogenous ET-1 in the development of cardiac hypertrophy due to pressure overload.Entities:
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Year: 1993 PMID： 8405444 DOI： 10.1016/0014-5793(93)80476-b
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124